Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
基本信息
- 批准号:3367198
- 负责人:
- 金额:$ 22.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1993
- 资助国家:美国
- 起止时间:1993-05-01 至 1996-04-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Our recent studies have shown that a primary genetic component of
hypertension in the spontaneously hypertensive rat (SHR) is on the Y
chromosome. We have developed two new, unique F12 substrains of SHR
designated SHR/y and SHR/a, which allow the manipulation of the effects
of the Y chromosome. The SHR/y substrain contains a hypertensive Y
chromosome in a normotensive autosomal background. The SHR/a substrain
contains a normotensive Y chromosome in a hypertensive autosomal
background. The hypothesis of this study is that the sympathetic nervous
system and the testes interact to produce an elevated blood pressure that
is sex linked and one component is ont he Y chromosome. To accomplish
this we will: 1) determine the impact of the Y chromosome on sympathetic
nervous system responsiveness and the testes, and 2) determine the
genetic interaction of the Y chromosome in hypertensive and normotensive
genetic backgrounds. Preliminary data suggests that the sympathetic
nervous system (SNS) is modulated by the hypertensive Y chromosome. By
comparing central and peripheral SNS indicators, steroid profiles, salt
sensitivity and salt appetite in the SHR/y and SHR/a substrains we will
determine which of these parameters are influenced by the Y chromosome.
Based on our results of backcross progeny, the dominant/recessive
relationship of the SHR and WKY hypertensive autosomal genes is modified
by the Y chromosome. Crosses between the SHR/y and SHR/a substrains and
SHR and WKY will be used to investigate this interaction. Finally,
matings of our SHR/y substrain to other normotensive inbred rat strains
will be used to determine the effect of the hypertensive Y chromosome in
other genetic backgrounds to discover modifier loci.
我们最近的研究表明,一个主要的遗传成分
项目成果
期刊论文数量(0)
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会议论文数量(0)
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