Tyrosine Hydroxylase Sry and Hypertension

酪氨酸羟化酶与高血压

基本信息

  • 批准号:
    7385950
  • 负责人:
  • 金额:
    $ 34.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-04-01 至 2010-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Hypertension affects about 25% of individuals in Western are affected more than females in most mammalian populations. Human studies from England, Australia, Japan and Sweden have shown that blood pressure is higher in males with hypertensive fathers compared to those with hypertensive mothers. These findings support our hypothesis that a locus on the Y chromosome can cause blood pressure to increase in an animal genetic model of hypertension as found in humans. A consomic rat strain developed in our laboratory by backcrossing hypertensive SHR and normotensive WKY for over 19 generations has produced a strain that has a Y chromosome from a hypertensive father and the rest of the genome is derived from a normotensive WKY. This unique animal strain has an important locus on the Y chromosome that significantly increases blood pressure. We propose that this locus is the Sry gene and males have at least one mutation in the consomic strain. The main hypothesis of this proposal is that a mutant locus on the Y chromosome is the primary cause of the increased blood pressure through the mechanism of regulating tyrosine hydroxylase, the rate limiting enzyme in catecholamine synthesis. Experiments will be done that examine Sry expression patterns in kidney and adrenal gland before and during the time which blood pressure is increasing. Experiments will be performed to determine if Sry follows a similar expression pattern as seen with tyrosine hydroxylase. Finally, Sry gene delivery to kidney and adrenal gland will demonstrate that blood pressure follows the elevation of Sry and tyrosine hydroxylase. Kidney function will be assessed by renal blood flow and urinary excretion tests before and after Sry gene delivery. Blood pressure will be measured by telemetry and blood flow velocity by Doppler flow probe in conscious animals. The results of these animal studies should enhance our understanding of the mechanism of the Y chromosome effect upon blood pressure in humans.
描述(由申请人提供):高血压影响西方约25%的个体,在大多数哺乳动物种群中,高血压的影响程度高于女性。来自英国、澳大利亚、日本和瑞典的人类研究表明,与高血压母亲相比,父亲患有高血压的男性血压更高。这些发现支持了我们的假设,即Y染色体上的一个位点可以导致高血压动物遗传模型中的血压升高,就像在人类中发现的那样。在我们实验室通过回交高血压SHR和血压正常的WKY超过19代而开发的consomic大鼠品系产生了一种品系,其具有来自高血压父亲的Y染色体,其余基因组来自血压正常的WKY。这种独特的动物品系在Y染色体上有一个重要的基因座,可以显着增加血压。我们建议,这个位点是Sry基因和男性至少有一个突变的consomic株。这一建议的主要假设是,Y染色体上的突变位点是通过调节酪氨酸羟化酶(儿茶酚胺合成中的限速酶)的机制导致血压升高的主要原因。将进行实验,检查血压升高之前和期间肾脏和肾上腺中的Sry表达模式。将进行实验以确定Sry是否遵循与酪氨酸羟化酶类似的表达模式。最后,将Sry基因递送至肾脏和肾上腺将证明血压跟随Sry和酪氨酸羟化酶的升高。在Sry基因递送之前和之后,将通过肾血流量和尿排泄测试来评估肾功能。将通过遥测测量清醒动物的血压,并通过多普勒血流探头测量血流速度。这些动物研究的结果应该增强我们对Y染色体对人类血压影响机制的理解。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DANIEL L ELY其他文献

DANIEL L ELY的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DANIEL L ELY', 18)}}的其他基金

Tyrosine Hydroxylase Sry and Hypertension
酪氨酸羟化酶与高血压
  • 批准号:
    6918324
  • 财政年份:
    2005
  • 资助金额:
    $ 34.85万
  • 项目类别:
Tyrosine Hydroxylase Sry and Hypertension
酪氨酸羟化酶与高血压
  • 批准号:
    7034596
  • 财政年份:
    2005
  • 资助金额:
    $ 34.85万
  • 项目类别:
Tyrosine Hydroxylase Sry and Hypertension
酪氨酸羟化酶与高血压
  • 批准号:
    7588770
  • 财政年份:
    2005
  • 资助金额:
    $ 34.85万
  • 项目类别:
Tyrosine Hydroxylase Sry and Hypertension
酪氨酸羟化酶与高血压
  • 批准号:
    7212081
  • 财政年份:
    2005
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2224127
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2910548
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2224128
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2702208
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2224126
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    3367198
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了