Tyrosine Hydroxylase Sry and Hypertension

酪氨酸羟化酶与高血压

基本信息

  • 批准号:
    7385950
  • 负责人:
  • 金额:
    $ 34.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2005
  • 资助国家:
    美国
  • 起止时间:
    2005-04-01 至 2010-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Hypertension affects about 25% of individuals in Western are affected more than females in most mammalian populations. Human studies from England, Australia, Japan and Sweden have shown that blood pressure is higher in males with hypertensive fathers compared to those with hypertensive mothers. These findings support our hypothesis that a locus on the Y chromosome can cause blood pressure to increase in an animal genetic model of hypertension as found in humans. A consomic rat strain developed in our laboratory by backcrossing hypertensive SHR and normotensive WKY for over 19 generations has produced a strain that has a Y chromosome from a hypertensive father and the rest of the genome is derived from a normotensive WKY. This unique animal strain has an important locus on the Y chromosome that significantly increases blood pressure. We propose that this locus is the Sry gene and males have at least one mutation in the consomic strain. The main hypothesis of this proposal is that a mutant locus on the Y chromosome is the primary cause of the increased blood pressure through the mechanism of regulating tyrosine hydroxylase, the rate limiting enzyme in catecholamine synthesis. Experiments will be done that examine Sry expression patterns in kidney and adrenal gland before and during the time which blood pressure is increasing. Experiments will be performed to determine if Sry follows a similar expression pattern as seen with tyrosine hydroxylase. Finally, Sry gene delivery to kidney and adrenal gland will demonstrate that blood pressure follows the elevation of Sry and tyrosine hydroxylase. Kidney function will be assessed by renal blood flow and urinary excretion tests before and after Sry gene delivery. Blood pressure will be measured by telemetry and blood flow velocity by Doppler flow probe in conscious animals. The results of these animal studies should enhance our understanding of the mechanism of the Y chromosome effect upon blood pressure in humans.
描述(由申请人提供):在西方,高血压对大约 25% 的个体的影响比大多数哺乳动物群体中的雌性更严重。英国、澳大利亚、日本和瑞典的人体研究表明,父亲患有高血压的男性血压高于母亲患有高血压的男性。这些发现支持了我们的假设,即在人类高血压的动物遗传模型中,Y 染色体上的一个基因座可导致血压升高。我们实验室通过将高血压 SHR 和正常血压 WKY 回交超过 19 代而开发出一种康体大鼠品系,该品系具有来自高血压父亲的 Y 染色体,而其余基因组则来自正常血压 WKY。这种独特的动物品系在 Y 染色体上有一个重要的位点,可以显着增加血压。我们推测这个位点是 Sry 基因,并且雄性在 consomic 品系中至少有一个突变。该提议的主要假设是,Y 染色体上的突变位点是通过调节酪氨酸羟化酶(儿茶酚胺合成中的限速酶)的机制导致血压升高的主要原因。将进行实验来检查血压升高之前和期间肾脏和肾上腺中的 Sry 表达模式。将进行实验以确定 Sry 是否遵循与酪氨酸羟化酶相似的表达模式。最后,将 Sry 基因递送至肾脏和肾上腺将证明血压随着 Sry 和酪氨酸羟化酶的升高而变化。在 Sry 基因递送之前和之后,将通过肾血流和尿液排泄测试来评估肾功能。将通过遥测技术测量血压,并通过多普勒血流探头测量有意识的动物的血流速度。这些动物研究的结果应该会增强我们对 Y 染色体对人类血压影响机制的理解。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

DANIEL L ELY其他文献

DANIEL L ELY的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('DANIEL L ELY', 18)}}的其他基金

Tyrosine Hydroxylase Sry and Hypertension
酪氨酸羟化酶与高血压
  • 批准号:
    6918324
  • 财政年份:
    2005
  • 资助金额:
    $ 34.85万
  • 项目类别:
Tyrosine Hydroxylase Sry and Hypertension
酪氨酸羟化酶与高血压
  • 批准号:
    7034596
  • 财政年份:
    2005
  • 资助金额:
    $ 34.85万
  • 项目类别:
Tyrosine Hydroxylase Sry and Hypertension
酪氨酸羟化酶与高血压
  • 批准号:
    7588770
  • 财政年份:
    2005
  • 资助金额:
    $ 34.85万
  • 项目类别:
Tyrosine Hydroxylase Sry and Hypertension
酪氨酸羟化酶与高血压
  • 批准号:
    7212081
  • 财政年份:
    2005
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2910548
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2224127
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2224128
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2702208
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    2224126
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:
Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
  • 批准号:
    3367198
  • 财政年份:
    1993
  • 资助金额:
    $ 34.85万
  • 项目类别:

相似海外基金

RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Standard Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Standard Grant
How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Training Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Fellowship
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Research Grant
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Studentship
ERI: Developing a Trust-supporting Design Framework with Affect for Human-AI Collaboration
ERI:开发一个支持信任的设计框架,影响人类与人工智能的协作
  • 批准号:
    2301846
  • 财政年份:
    2023
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Standard Grant
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Operating Grants
How motor impairments due to neurodegenerative diseases affect masticatory movements
神经退行性疾病引起的运动障碍如何影响咀嚼运动
  • 批准号:
    23K16076
  • 财政年份:
    2023
  • 资助金额:
    $ 34.85万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了