Y CHROMOSOME AND HYPERTENSION
Y 染色体与高血压
基本信息
- 批准号:2910548
- 负责人:
- 金额:$ 26.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1993
- 资助国家:美国
- 起止时间:1993-05-01 至 2000-04-30
- 项目状态:已结题
- 来源:
- 关键词:androgen receptor autosomal recessive trait biomarker dietary sodium familial hypertension genetic strain histogenesis kidney metabolism male molecular cloning norepinephrine renin angiotensin system sex linked trait spontaneous hypertensive rat stress proteins sulfatases sympathetic nervous system testicular feminization testosterone
项目摘要
The long term objectives of this application are to understand the
mechanisms by which the Y chromosome from spontaneously hypertensive rats
(SHR) produces a significant blood pressure rise. The Y chromosome blood
pressure effect has now been documented in two other independent
laboratories but the genetic and physiological mechanisms are not known.
There appears to be both sympathetic nervous system (SNS) and androgen
components to the Y mediated blood pressure effect. This research will
benefit our understanding of one of the genetic components of hypertension
and parallels what is observed in human populations. The specific aims
will focus on: l) how the SNS may influence testicular development,
vascular reactivity and renal metabolism of norepinephrine, 2) if
gonadotropin releasing hormone may be released early due to the Y
chromosome, 3) if the Y chromosome enhances salt sensitivity, 4)
identification and cloning of the heat shock protein sequence on the Y
chromosome and 5) determination of the mechanism of the Y chromosome
influence on steroid sulfatase in specific tissues. These aims will be
accomplished by using both physiological, genetic and molecular
techniques. Blood pressure will be measured by telemetry in several
studies throughout' the prepubertal and pubertal stages during which blood
pressure rapidly rises. molecular studies measuring components of the
renin angiotensin system in testes and kidney will be examined and heat
shock protein expression will be determined in relevant target organs,
such as, aorta, resistance 'vessels, kidney, heart and adrenal glands.
Biochemical measurements of indices of the SNS will evaluate the mechanism
of elevated adrenergic responsiveness (increased norepinephrine content,
release, turnover) in target' organs influencing blood pressure. in some
experiments the genetically testicular feminized male will be studied to
determine the interaction of the Y chromosome, androgens, androgen
receptor and the SNS upon blood pressure. The results of these studies
should enhance our understanding of the mechanism of the Y chromosome
effect upon blood pressure.
这个应用程序的长期目标是理解
项目成果
期刊论文数量(18)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Sodium intake is increased by social stress and the Y chromosome and reduced by clonidine.
社会压力和 Y 染色体会增加钠的摄入量,可乐定会减少钠的摄入量。
- DOI:10.1152/ajpregu.2000.278.2.r407
- 发表时间:2000
- 期刊:
- 影响因子:0
- 作者:Ely,D;Herman,M;Ely,L;Barrett,L;Milsted,A
- 通讯作者:Milsted,A
The SHR Y-chromosome increases testosterone and aggression, but decreases serotonin as compared to the WKY Y-chromosome in the rat model.
在大鼠模型中,与 WKY Y 染色体相比,SHR Y 染色体会增加睾酮和攻击性,但会降低血清素。
- DOI:10.1023/b:bege.0000038489.82589.6f
- 发表时间:2004
- 期刊:
- 影响因子:0
- 作者:Toot,Jonathan;Dunphy,Gail;Turner,Monte;Ely,Daniel
- 通讯作者:Ely,Daniel
Overview of dietary sodium effects on and interactions with cardiovascular and neuroendocrine functions.
膳食钠对心血管和神经内分泌功能的影响及其相互作用概述。
- DOI:10.1093/ajcn/65.2.594s
- 发表时间:1997
- 期刊:
- 影响因子:0
- 作者:Ely,DL
- 通讯作者:Ely,DL
The spontaneously hypertensive rat Y chromosome produces an early testosterone rise in normotensive rats
自发性高血压大鼠 Y 染色体导致正常血压大鼠早期睾酮升高
- DOI:10.1097/00004872-199407000-00007
- 发表时间:1994
- 期刊:
- 影响因子:4.9
- 作者:D. Ely;Jessica Falvo;G. Dunphy;A. Caplea;R. Salisbury;M. Turner
- 通讯作者:M. Turner
SHR Y chromosome enhances the nocturnal blood pressure in socially interacting rats.
SHR Y 染色体可提高社交大鼠的夜间血压。
- DOI:10.1152/ajpheart.2000.279.1.h58
- 发表时间:2000
- 期刊:
- 影响因子:0
- 作者:Caplea,A;Seachrist,D;Dunphy,G;Ely,D
- 通讯作者:Ely,D
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