Impaired fear inhibition in adolescence

点击翻译按钮获取中文摘要

This project aims to test whether an imbalance in the adolescent brain impairs fear regulation. Recent evidence shows that adolescents, both rodent and human, do not effectively inhibit fear. This project will systematically isolate the role of specific neural circuits by selectively manipulating their activity in a cell type specific manner during fear inhibition in adolescent rats. Understanding neural processes that impair fear regulation during a vulnerable period of development could lead to a more complete neurobiological theory of fear regulation in adolescence, and improve treatments for anxious youth.