A window of vulnerability: Impaired fear inhibition in adolescent rats

脆弱之窗：青春期大鼠的恐惧抑制能力受损

• 批准号: nhmrc : 1086855
• 负责人: Dr Kathryn Baker
• 金额: $ 22.39万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/window-vulnerability-impaired-adolescent-rats/519153
• 关键词: window; vulnerability; Impaired; fear; inhibition

Adolescence is a period of increased vulnerability to anxiety disorders. The brain undergoes substantial maturation during adolescence, particularly the prefrontal cortex (PFC), a region critical for inhibiting fear. This project examines why fear inhibition is impaired in adolescents and compares the neural mechanisms mediating treatments that enhance fear reduction in adolescence. This research adds new knowledge about novel approaches for early interventions for adolescent anxiety.

青春期是焦虑症的易感性增加的时期。大脑在青春期经历了实质性的成熟，特别是前额叶皮层（PFC），这是抑制恐惧的关键区域。这个项目探讨了为什么恐惧抑制在青少年中受损，并比较了神经机制介导的治疗，提高恐惧减少青春期。这项研究为青少年焦虑的早期干预增加了新的知识。