MOLECULAR MECHANISMS FOR A SCHIZOPHRENIC MARKER

在我们最初发现左侧组织学异常之后 对于精神分裂症患者的海马区，我们计划将我们的研究扩展到 这些患者的右侧海马体和小脑及其 年龄匹配的对照组。大脑样本来自一组大约 年龄匹配的躁郁症患者也将接受检查，以确定 脑海马细胞的组织模式是否受到干扰 精神分裂症以外的精神病患者。这一增加还将使我们能够 对已报道的右半球障碍与情感性的关系进行检验 精神分裂症患者的疾病和左半球功能障碍。搜索 对于小脑组织结构的改变是由1) 许多精神分裂症患者CT扫描中真性萎缩的存在 以及2)发现了极短潜伏期传导通路 边缘系统的小脑内侧和隔海马区成分。 对我们最初的发现的确认和扩展可能会有相当大的意义 了解精神分裂症患者发病因素的重要性。

Following our initial discovery of histological anomalies in the left hippocampi of schizophrenic patients, we plan to extend our studies to the right hippocampus and to the cerebellum of these patients and their age-matched controls. Brain specimens from a group of approximately age-matched manic-depressive patients will also be examined to determine whether organizational patterns of hippocampal cells are disturbed in psychoses other than schizophrenia. This addition will also enable us to test the reported relationship of right hemispheric disorder with affective illness and left hemispheric dysfunction with schizophrenia. The search for alterations in cerebellar histological structure is motivated by 1) the presence of vermal atrophy in the CT scans of many schizophrenic patients and 2) the discovery of very short latency conduction pathways between medial cerebellum and septohippocampal components of the limbic system. Confirmation and extension of our original findings may be of considerable importance in understanding pathogenetic factors in the schizophrenics.