HIPPOCAMPAL AND CEREBELLAR ANOMALIES IN SCHIZOPHRENIA

在我们最初发现左侧的组织学异常后， 为了研究精神分裂症患者，我们计划将我们的研究扩展到 这些患者的右侧海马体和小脑， 年龄匹配的对照组。 从一组大约 年龄匹配的躁狂抑郁症患者也将进行检查，以确定 海马细胞的组织模式是否受到干扰， 精神分裂症以外的精神病 这一补充还将使我们能够 测试报告的右半球障碍与情感障碍之间的关系， 精神分裂症患者的左半球功能障碍 搜索 小脑组织学结构的改变是由1） 在许多精神分裂症患者的CT扫描中出现了眼睑萎缩 和2）发现非常短的潜伏期传导通路之间 小脑内侧和边缘系统的隔海马组成部分。 证实和扩展我们最初的发现可能是相当重要的 对了解精神分裂症发病因素的重要性。

Following our initial discovery of histological anomalies in the left hippocampi of schizophrenic patients, we plan to extend our studies to the right hippocampus and to the cerebellum of these patients and their age-matched controls. Brain specimens from a group of approximately age-matched manic-depressive patients will also be examined to determine whether organizational patterns of hippocampal cells are disturbed in psychoses other than schizophrenia. This addition will also enable us to test the reported relationship of right hemispheric disorder with affective illness and left hemispheric dysfunction with schizophrenia. The search for alterations in cerebellar histological structure is motivated by 1) the presence of vermal atrophy in the CT scans of many schizophrenic patients and 2) the discovery of very short latency conduction pathways between medial cerebellum and septohippocampal components of the limbic system. Confirmation and extension of our original findings may be of considerable importance in understanding pathogenetic factors in the schizophrenics.