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ELECTROCONVULSIVE SHOCK EFFECTS ON BRAIN RECEPTORS

电休克对脑感受器的影响

基本信息

批准号：
3380666
负责人：
KENNETH J KELLAR
金额：
$ 15.06万
依托单位：
GEORGETOWN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1986
资助国家：
美国
起止时间：
1986-07-01 至 1991-06-30
项目状态：
已结题

项目摘要

The overall objectives of this research are to compare the effects of administration of electroconvulsive shock (ECS) and antidepressant drugs on serotonergic and noradrenergic receptors in rat brain. In particular, the following hypotheses will be tested: 1) that ECS differs from most antidepressant drug treatments in its effects on 5-HT-2 receptors, and 2) that ECS differs from most antidepressant drug treatments in its effects on up-regulated beta-adrenergic receptors. To test the latter hypothesis, we will use a new model in which following highly specific lesions of 5-HT neurons or inhibition of 5-HT synthesis, beta-adrenergic receptors are markedly increased in brain. Among the specific aims of this research are: 1) To determine the effects of ECS and antidepressant drugs on the increased number of beta-adrenergic receptors by measuring ligand binding and isoproterenol-stimulated cyclic AMP production in brain. 2) To use quantitative autoradiography to identify and compare the specific brain regions in which beta-adrenergic receptors are decreased by ECS and antidepressant drugs, and to identify the beta receptor subtype affected by these treatments. 3) To identify by quantitative autoradiography the specific regions and layers of cerebral cortex in which 5-HT-2 receptors are increased by ECS and decreased by antidepressant drugs. 4) To compare the effects of ECS and antidepressant drugs on 5-HT-2 and alpha-1-adrenergic receptor-mediated phosphoinositide hydrolysis. 5) To determine whether lesions of norepinephrine axons alter the effects of ECS or antidepressant drugs on 5-HT-2 receptors. These studies should provide new information about the effects of ECS and antidepressant drugs on the receptor systems for the two neurotransmitters that have been most often implicated in depression and its treatment. This information should contribute to an eventual understanding of the neurochemical effects of ECS and antidepressant drugs and potentially to the rationale for the clinical effects of electroconvulsive therapy.

本研究的总体目标是比较

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Electroconvulsive shocks increase the concentration of neocortical and hippocampal neuropeptide Y (NPY)-like immunoreactivity in the rat.

电休克会增加大鼠新皮质和海马神经肽 Y (NPY) 样免疫反应性的浓度。

DOI：
10.1016/0006-8993(90)90523-e
发表时间：
1990
期刊：
Brain research
影响因子：
2.9
作者：
Wahlestedt,C;Blendy,JA;Kellar,KJ;Heilig,M;Widerlöv,E;Ekman,R
通讯作者：
Ekman,R

Electroconvulsive shock and reserpine increase alpha 1-adrenoceptor binding sites but not norepinephrine-stimulated phosphoinositide hydrolysis in rat brain.

电休克和利血平会增加大鼠脑中α1-肾上腺素受体的结合位点，但不会增加去甲肾上腺素刺激的磷酸肌醇水解。

DOI：
10.1016/0014-2999(88)90330-5
发表时间：
1988
期刊：
European journal of pharmacology
影响因子：
5
作者：
Blendy,JA;Stockmeier,CA;Kellar,KJ
通讯作者：
Kellar,KJ

Electroconvulsive shock increases alpha 1b- but not alpha 1a-adrenoceptor binding sites in rat cerebral cortex.

电休克会增加大鼠大脑皮层中 α1b- 肾上腺素受体的结合位点，但不会增加 α1a- 肾上腺素受体的结合位点。

DOI：
10.1111/j.1471-4159.1991.tb06350.x
发表时间：
1991
期刊：
Journal of neurochemistry
影响因子：
4.7
作者：
Blendy,JA;Perry,DC;Pabreza,LA;Kellar,KJ
通讯作者：
Kellar,KJ

Electroconvulsive shock differentially increases binding to alpha-1 adrenergic receptor subtypes in discrete regions of rat brain.

电休克不同程度地增加了大鼠大脑离散区域中与 α-1 肾上腺素能受体亚型的结合。

DOI：
10.1523/jneurosci.10-08-02580.1990
发表时间：
1990
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
0
作者：
Blendy,JA;Grimm,LJ;Perry,DC;West-Johnsrud,L;Kellar,KJ
通讯作者：
Kellar,KJ

Electroconvulsive shock but not antidepressant drugs increases alpha 1-adrenoceptor binding sites in rat brain.

电休克会增加大鼠大脑中的α1-肾上腺素受体结合位点，但抗抑郁药物不会增加。