SENSORIMOTOR CORTEX IN PROSIMIAN PRIMATE

原猴灵长类动物的感觉运动皮层

• 批准号: 3378170
• 负责人: MARY L CARLSON
• 金额: $ 8.51万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-12-01 至 1987-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3378170
• 关键词: brain mapping; experimental brain lesion; neurophysiology; peripheral nervous system disorders; sensorimotor system; sensory discrimination; sensory mechanism; sensory thresholds; somatic afferent nerve; touch

All mammalian species appear to have two major somatic sensory projection areas in the sensorimotor region of the cerebral cortex, SmI and SmII. Both projection areas receive low-threshold cutaneous input from the contralateral body surface, but most prominantly from the hand. Unilateral lesions of the SmI or SmII hand areas produce severe behavioral deficits in texture discrimination capacity. However the response properties of cells in these two areas in non-primate species suggest they may contribute differently to the ability to discriminate the spatiotemporal features of textured surfaces. With a continuing interest in sensorimotor cortex and tactile function in primates, we intend to study Galago to determine: 1) the physiological organization and cytoarchitectonic features of SmII; 2) texture discrimination deficits following selective removal of SmI or SmII glabrous hand areas; 3) the response properties of SmI and SmII neurons to hand-held punctate stimuli and to drum-rotated textured surfaces in normal animals. In these multidisciplinary studies we will examine the conributions of SmI and SmII to texture discrimination capacity, as suggested by behavioral consequences of cortical lesions and by the physiological properties of constituent neurons. We proposed these studies in Galago, as it is a primate species in which both SmI and SmII are more simply organized and more easily accessible than in Macaca and other anthropoid primates. However, we expect the findings of SI and SII in Galago to be generalizable to more complex and recently-evolved primates. These studies of the physiological basis of tactile discrimination are expected to demonstrate specific neural mechanism in perceptual phenomenon. An understanding of neural basis for somatic sensation has significance for perceptual abnormalities so common in psychiatric and neurological disorders.

所有哺乳动物似乎都有两个主要的躯体感觉投射 大脑皮层感觉运动区的SmI和SmII。 两个投影区域都接收来自皮肤的低阈值皮肤输入。 对侧身体表面，但最有害的是从手。 单方面 SmI或SmII手部区域的病变会导致严重的行为缺陷， 纹理辨别能力 然而细胞的反应特性 在这两个区域的非灵长类动物表明， 不同的能力，以区分时空特征， 纹理表面。 随着对感觉运动皮层的持续兴趣， 在灵长类动物的触觉功能，我们打算研究Galago，以确定：1） SmII的生理组织和细胞结构特征; 2） 选择性去除SmI或SmII后的纹理辨别缺陷 无毛手区; 3）SmI和SmII神经元的反应特性， 手持点状刺激和鼓旋转纹理表面在正常 动物 在这些多学科研究中，我们将研究 SmI和SmII对纹理辨别能力的贡献， 这是由皮层损伤的行为后果和 组成神经元的生理特性。 我们提出了这些研究 在加拉哥，因为它是一个灵长类物种，其中SmI和SmII都更多 组织简单，比Macaca和其他地方更容易进入 灵长类动物。 然而，我们预计SI和SII的结果将在 Galago可以推广到更复杂和最近进化的灵长类动物。 这些触觉辨别的生理学基础的研究是 预期将在知觉中展示特定的神经机制 现象 对躯体感觉的神经基础的理解 知觉异常在精神病和 神经系统疾病