CELLULAR BIOPHYSICS OF NEUROMUSCULAR FUNCTION

这个项目的目标之一是了解 收缩是由膜的电位变化启动和控制的 骨骼肌系统。细胞的电学和膜性 将探索横管系统(T系统)和肌浆网 使用光学方法(荧光、染料吸收和外部荧光 方法)以及常规电生理技术。我们 我特别想知道关于作用的径向传导的细节 通过T系统的电势和关于膜电势的变化 兴奋收缩偶联过程中的肌浆网。另一个目标是 本课题旨在研究突触传递过程中的疲劳机制。 通过使用鱿鱼星状神经节。

One of the goals of this project is to understand the mechanisms by which contraction is initiated and controlled by potential changes of the membranous system of skeletal muscle. Electrical and membranous properties of the transverse tubular system (T-system) and sarcoplasmic reticulum will be explored by using optical methods (fluorescence dye absorption and external fluorescence method) as well as by the conventional electrophysiological techniques. We would particularly like to know details about the radial conduction of action potential through the T-system and about the membrane potential changes of sarcoplasmic reticulum during excitation-contraction coupling. Another goal of this project is to investigate the mechanism of fatigue in synaptic transmission by using the squid stellate ganglion.