CELLULAR BIOPHYSICS OF NEUROMUSCULAR FUNCTION

神经肌肉功能的细胞生物物理学

• 批准号: 3393785
• 负责人: SHIGEHIRO NAKAJIMA
• 金额: $ 12.17万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-12-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3393785
• 关键词: action potentials; biophysics; electrophysiology; fatigue; fluorescent dye /probe; fresh water environment; membrane permeability; membrane potentials; muscle contraction; neural information processing; neural transmission; neuromuscular function; neuromuscular transmission; saltwater environment; sarcoplasmic reticulum; striated muscles; synapses; viscosity

One of the goals of this project is to understand the mechanisms by which contraction is initiated and controlled by potential changes of the membranous system of skeletal muscle. Electrical and membranous properties of the transverse tubular system (T-system) and sarcoplasmic reticulum will be explored by using optical methods (fluorescence dye absorption and external fluorescence method) as well as by the conventional electrophysiological techniques. We would particularly like to know details about the radial conduction of action potential through the T-system and about the membrane potential changes of sarcoplasmic reticulum during excitation-contraction coupling. Another goal of this project is to investigate the mechanism of fatigue in synaptic transmission by using the squid stellate ganglion.

本项目的目标之一是了解 收缩是由膜的潜在变化发起和控制的 骨骼肌系统。 电和膜的性质， 将探讨横管系统（T系统）和肌浆网 通过使用光学方法（荧光染料吸收和外部荧光 方法）以及通过常规电生理学技术。 我们 我特别想知道关于径向传导的细节 电位通过T系统和关于膜电位的变化 在兴奋-收缩偶联过程中的肌浆网。 的另一个目标 本课题旨在研究疲劳在突触传递中的作用机制 利用鱿鱼星状神经节。