CEREBRAL CORTICAL CONTROL OF MOVEMENT

拟议研究的目的是增加我们对如何 运动皮层控制运动，并随后有助于更好地 治疗人类运动功能障碍。 在过去的几年里，我们 显示运动皮层直接从大脑皮层接收外周输入， 而不是通过感觉皮层。 我们已经展示了 运动皮质内的皮质传出区，其控制 单个肌肉，因此运动皮层和外周是通过 最简单的环路 在未来几年，我们计划阐明 各种输入汇聚到运动皮层。 会来做这项工作 将微刺激传递到中枢神经系统的各个部分， 检查使用皮质-外周环路的影响。 这项研究将 希望能进一步探索运动皮层， 将适用于患者的治疗。

The purpose of the proposed study is to increase our understanding of how the motor cortex controls movement and subsequently to contribute toward the better treatment of human motor dysfunctions. During the past grant years, we have shown that the motor cortex receives peripheral inputs directly from the thalamus and not through the sensory cortex. We have already shown there are cortical efferent zones within the motor cortex which control contraction of individual muscles, hence the motor cortex and the periphery are connected by the simplest loop circuit. During the coming years, we plan to elucidate the functional significance of various inputs converging into the motor cortex. This will be done by delivering microstimulation to various parts of the central nervous system and examining the effects using the cortico-peripheral loop circuit. The study will hopefully explore further insights of the motor cortex and yield knowledge which will be applicable to the treatment of the patients.