FAMILIAL TRANSMISSION OF SIMPLE PHOBIAS AND FEARS

这项建议是联合提出的多中心研究的一半。 巴洛和费尔提交了两份不同但相似的申请。 这项拟议的研究的目标是进行一项盲目的、可控的、 直接访谈DSM III-R单纯性恐惧症家系调查 家族性传播、亚型的异质性(例如 动物VS情境性BS血损伤)，与“亚障碍”的关系 非理性恐惧(即不符合障碍标准的非理性恐惧 由于缺乏与恐惧相关的回避、损害或耐力) 以及其他DSM III R焦虑症。 精神障碍的风险和一级亲属的症状 单纯性恐惧症先证者(SPD先证者，合并两个站点n=120) 与评估相似的Never的一级亲属的风险进行比较 精神失控。确定是否有独立的家族性 血液/损伤、动物和情景亚型、先证者的聚集 将按预期进行子类型划分，并对比各个子类型的风险 由此产生的亲属群体和没有控制不良的先证者的亲属 (NCP)。评估“亚障碍”非理性恐惧的家族聚集性 (SIF)及其与SPD的关系，SPD和NCP先证者组 将根据至少一个简单的非理性的存在或不存在而细分 恐惧(SIF)。SPD、SIF、两者或两者都不存在的风险将在以下方面进行对比 四个先证者群体的亲属(无SPD/无SIF，仅SIF， 仅SPD和SPD+SIF)。SPD亲属的家族性精神病理学研究 患者的先证者也将与60岁的亲属进行比较 未经治疗的“社区成员”自闭症先驱。 我们最初的目标是使用家庭研究方法来更清楚地 划定SPD和其他焦虑之间的病因学有效界限 疾病以及DSM III R SPD类别本身也是如此。我们的龙 学期目标包括这样一种可能性，即由于其离散性质， 和常见的，仔细研究单纯性恐惧症和 “亚无序”的非理性恐惧可能会导致一种独特的模式在 用来研究神经生理学之间的相互关系 变异、主观情感与认知、正常与发展 心理上的恐惧和回避行为。

This proposal is one half of a jointly proposed multicenter study by Drs. Barlow and Fyer who are submitting two separate but similar applications. The objective of the proposed study is to conduct a blind, controlled, direct interview family of DSM III R simple phobic disorder to investigate its familial transmission, heterogeneity with respect to subtype (e.g. animal vs situational bs blood injury), relationship to "subdisorder" irrational fears (i.e. irrational fears which do not meet disorder criteria due to lack of associated avoidance, impairment or endurance with dread) and to other DSM III R anxiety disorders. Risk for psychiatric disorder and symptoms of first degree relatives of simple phobia probands (SPD probands, combined two site n=120) will be compared to risk among similarly evaluated first degree relatives of never mentally ill controls. To determine if there is independent familial aggregation of the blood/injury, animal and situational subtypes, probands will be prospectively subtyped and risk for each subtype contrasted across the resulting relative groups and relatives of not ill control probands (NCP). To assess familial aggregation of "subdisorder" irrational fears (SIF) and their relationship to SPD, both the SPD and NCP proband groups will be subdivided by presence or absence of at least one simple irrational fear (SIF). Risks for SPD, SIF, both or neither will be contrasted across relatives of the four resulting proband groups (No SPD/No SIF, SIF Only, SPD Only, and SPD+SIF). Familial psychopathology among relatives of SPD patient probands will also be compared to that of relatives of 60 untreated"community member" SPD probands. Our initial objective is to use the family study method to more clearly delineate etiologically valid boundaries both between SPD and other anxiety disorders as well as within the DSM III R SPD category itself. Our long term goals include the possibility that because of their discrete nature and common occurrence, careful study of simple phobic disorders and "subdisorder" irrational fears may lead to development of a unique model in which to investigate inter-relationships between neurophysiological variation, subjective affect and cognition, and development of normal and psychopathological fear and avoidance behavior.