PSYCHOBIOLOGY/GENETICS/TREATMENT OF ANXIETY DISORDERS

该计划项目拨款是一项多学科的尝试，以处理 焦虑症的复杂性。我们的原创 从生理学角度验证DSM-III障碍的努力， 对挑衅的反应和家庭研究，现在扩展到处理 还伴随着横截面和发展的复杂问题 共病。 我们的团队现在包括雷切尔·吉特曼、克莱恩和米尔娜·魏斯曼； 临床发展和纵向研究方面的专家 样本、家庭研究和流行病学样本。 雷切尔·克莱因将继续对 患有惊恐障碍、社交恐惧症、广场恐惧症的患者 恐惧症和正常人。 Myrna Weissman将研究已经收集的ECA数据，这是 现在准备好进行完整的跨站点分析，从而应用 流行聚集性变量和危险因素对艾滋病的影响 证候验证问题。 杰克·戈尔曼关于过度通风和二氧化碳的项目赠款 这项拨款放大了恐慌症的敏感度 包括社交恐惧症和强迫症。三十五岁 二氧化碳的百分比挑战允许进一步研究 恐慌症患者的二氧化碳剂量反应曲线 障碍、社交恐惧症、强迫症和正常 控制。为了控制认知和预期的影响， 将与增加的呼吸道阻力进行比较。 这项家庭研究将探讨共病和 惊恐障碍、社交恐惧症、广场恐惧症的异质性 恐惧症与两类正常人(熟人和亲属 普通熟人)。一级亲属盲目随诊 将提供有关焦虑症发病的信息 这一高危人群以及未经治疗的自然病史 病人。将对选定的家系进行DNA分析 作者：James Gusella和Jurg Ott。

This Program Project Grant is a multidisciplinary attempt to deal with the complexities of the anxiety disorders. Our original effort to validate the DSM-III disorders in terms of physioloqy, response to provocation, and family study, is now extended to deal also with the complex issue of cross sectional and developmental co-morbidity. Our team now includes Rachel Gittelman Klein and Myrna Weissman; experts in the developmental and longitudinal study of clinical samples, family studies, and epidemiological samples. Rachel Klein will pursue the systematic study of the offspring of patients with panic disorder, social phobia, agoraphobia, simple phobia and normals. Myrna Weissman will study the already gathered ECA data, which is now ready for complete cross-site analyses, thus applying the variables of epidemiological aggregation and risk factors to the problem of syndromal validation. Jack Gorman's project grant on hyperventilation and carbon dioxide sensitivity in panic disorders is amplified by this grant to include social phobics and obsessive compulsives. Thirty-five percent carbon dioxide challenges allow for yet further study of the carbon dioxide dose response curve in patients with panic disorder, social phobia, obsessive compulsive disorder and normal controls. To control for cognitive and expectation effects a comparison with increased airway resistance will be conducted. The family study will pursue the issue of comorbidity and heterogeneity in panic disorder, social phobia, agoraphobia, simple phobia and two classes of normals (acquaintances and relatives of normal acquaintances). Blind followup of first degree relatives of anxiety disorders will provide information concerning onset of this high risk group as well as the natural history of untreated sick people. DNA analyses of selected pedigrees will be conducted in collaboration with James Gusella and Jurg Ott.