COST-EFFECTIVENESS OF SIX TREATMENTS FOR SCHIZOPHRENIA

描述：（改编自申请人摘要）： 本研究探讨了6种门诊治疗的成本效益 正在进行的NIMH“治疗策略”中实施的精神分裂症 精神分裂症”（TSS）合作研究。 TSS研究是一项为期8年的5中心合作临床试验， 检查3种抗精神病药物维持策略（标准，低， 和间歇剂量）与2个心理社会家庭联合使用 干预措施（应用行为和支持），3x2因子 设计 早期的研究分别证明了 剂量减少和家庭干预，但TSS研究是第一个 研究药物治疗和家庭治疗的相互作用。 的 TSS研究将涉及约370例研究诊断患者 精神分裂症、情感障碍或精神分裂样障碍 他们一直在与自己的家人保持联系。 拟议的成本效益研究利用了 仔细比较6口井的相对成本效益， 在一个定义明确的社区实施精神分裂症的社区治疗， 5个临床试验机构的患者人群。 该研究将列举 精神分裂症疾病的社会成本，比较 使用各种有效性措施的治疗，并比较 每个治疗组产生的不同类型的费用。

DESCRIPTION: (Adapted from Applicant's Abstract): This study examines the cost-effectiveness of the 6 outpatient treatments for schizophrenia implemented in the ongoing NIMH "Treatment Strategies in Schizophrenia" (TSS) cooperative study. The TSS study is a 5-site, 8-Year collaborative clinical trial which examines 3 antipsychotic medication maintenance strategies (standard, low, and intermittent dose) in combination with 2 psychosocial family interventions (applied behavioral and supportive ) in a 3x2 factorial design. Earlier studies have demonstrated separately the effectiveness of dose reduction and family interventions, but the TSS study is the first to examine the interactive effects of medication and family treatments. The TSS study will involve approximately 370 patients with research diagnoses of schizophrenia, schizoaffective disorder, or schizophreniform disorder who are in ongoing contact with their family of origin. The proposed cost-effectiveness study capitalizes on the unique opportunity to compare the relative cost-effectiveness of 6 well specified, carefully implemented community treatments for schizophrenia in a well-defined patient population at 5 clinical sites. The study will enumerate the societal costs of schizophrenic illness, compare the cost-effectiveness of the treatments using a variety of effectiveness measures, and compare the different types of costs incurred by each treatment group.