COST-EFFECTIVENESS OF SIX TREATMENTS FOR SCHIZOPHRENIA

描述：(改编自申请人摘要)： 这项研究考察了6种门诊治疗的成本效益。 对正在进行的NIMH治疗策略中实施的精神分裂症 精神分裂症“(TSS)合作研究。 TSS研究是一项为期8年的5个站点的合作临床试验， 检查3种抗精神病药物维持策略(标准、低、 和间歇剂量)与2个心理社会家庭相结合 3x2因素中的干预措施(应用行为和支持性) 设计。早期的研究已经分别证明了 减少剂量和家庭干预，但TSS研究是第一次 检查药物和家庭治疗的交互作用。这个 TSS研究将涉及大约370名有研究诊断的患者 精神分裂症、分裂情感障碍或分裂样障碍 与其原籍家庭保持持续联系的人。 拟议的成本效益研究利用了这一独特的机会 要仔细比较6个具体的方案的相对成本效益 在定义明确的社区中实施精神分裂症治疗 5个临床点的病人人数。这项研究将列举 精神分裂症疾病的社会成本，比较 使用各种有效措施的治疗，并比较 每一治疗组产生的不同类型的费用。

DESCRIPTION: (Adapted from Applicant's Abstract): This study examines the cost-effectiveness of the 6 outpatient treatments for schizophrenia implemented in the ongoing NIMH "Treatment Strategies in Schizophrenia" (TSS) cooperative study. The TSS study is a 5-site, 8-Year collaborative clinical trial which examines 3 antipsychotic medication maintenance strategies (standard, low, and intermittent dose) in combination with 2 psychosocial family interventions (applied behavioral and supportive ) in a 3x2 factorial design. Earlier studies have demonstrated separately the effectiveness of dose reduction and family interventions, but the TSS study is the first to examine the interactive effects of medication and family treatments. The TSS study will involve approximately 370 patients with research diagnoses of schizophrenia, schizoaffective disorder, or schizophreniform disorder who are in ongoing contact with their family of origin. The proposed cost-effectiveness study capitalizes on the unique opportunity to compare the relative cost-effectiveness of 6 well specified, carefully implemented community treatments for schizophrenia in a well-defined patient population at 5 clinical sites. The study will enumerate the societal costs of schizophrenic illness, compare the cost-effectiveness of the treatments using a variety of effectiveness measures, and compare the different types of costs incurred by each treatment group.