SERVICES TRIAL METHODS: CLOZAPINE COST EFFECTIVENESS

(摘自申请者摘要)：氯氮平是一种新型的 可能对服务利用和服务产生深远影响的抗精神病药物 治疗结果--抗药性、严重和永久性残疾 精神分裂症患者。然而，氯氮平的治疗费用很高。这个 替代公共精神卫生系统政策的真实财务影响 关于氯氮平的分配，治疗应有所了解。缺乏 此信息可能会导致无法为该残疾群体提供服务 有效地和浪费了公共治疗资源。此信息 应尽快获得，并以最 适用于公共精神卫生系统关于资源的决策 分配。因此，一种新的州际和公共学术模式 研究协作的建议是： 1)借鉴经验丰富的公共精神卫生系统和大学 一项国家规划工作的调查人员， 2)提供了加速试验计划的设计“工具包”， 3)为国家精神健康提供可获得的、有补贴的咨询 审判计划和执行当局， 4)提供国家数据分析支持，以及 5)汇集多个州的数据，以扩大结果的相关性。 这一方法也为公共学术界提供了一个很有前途的模式 关于其他新闻服务资源分配政策的协作 问题。 拟议中的项目将让州和大学的调查人员参与 规划开发氯氮平成本效益试验“工具包”的活动， 并支持实施 氯氮平在多个公共场所的合作试验。

(Adapted from applicant's abstract): Clozapine is a new type of neuroleptic that may have a profound impact on the service utilization and outcomes of treatment-resistent, severely and persistently disable schizophrenic patients. However, Clozapine treatment is expensive. The true financial impact of alternate public mental health system policies regarding the allocation of Clozapine treatment should be known. Lack of this information may result in both failure to serve this disabled group effectively and a waste of public treatment resources. This information should be obtained as soon as possible and in a form that is most applicable to public mental health system decisions regarding resource allocation. Therefore, a new model of interstate and public-academic research collaboration is proposed that: 1) Draws upon experienced public mental health system and university investigators for a national planning effort, 2) Offers a design "kit" to speed the planning of trials, 3) Offers accessible, subsidized consultation to state mental health authorities on trial planning and execution, 4) Offers a national data analysis support, and 5) Pools multi-state data to broaden the relevance of results. The approach also offers a promising model for public-academic collaboration on other pressing services resource allocation policy questions. The proposed project will engage state and university investigators in planning activities to develop a Clozapine cost-effectiveness trial "kit", and support consultation and coordination costs for implementing a cooperative Clozapine trial at multiple public sites.