NURSING ASSESSMENT OF PMS--NEUROMETRIC INDICES

经前综合症的护理评估--神经测量指标

• 批准号: 3392506
• 负责人: Ora Lea Strickland
• 金额: $ 26.95万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-08-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3392506
• 关键词: anxiety; cortisol; depression; disease /disorder classification; electroencephalography; female; human subject; longitudinal human study; neurophysiology; physiologic stressor; premenstrual syndrome; sign /symptom; statistics /biometry

The purposes of this research are to: (a) describe, compare, and contrast patterns of brain function through the use of neurometric analyses in women with perimenstrual turmoil symptoms and in women with no or mild perimenstrual symptoms, and; (b) determine the association of patterns of brain function with perimenstrual symptoms, anxiety, depression, and cortisol levels during postmentrual and perimenstrual phases among the symptomatic and asymptomatic women. The following research questions will be investigated: 1. Do women with perimenstrual turmoil have a higher incidence of psychopathology than asymptomatic women? 2. Is there a relationship between brain function and perimenstrual symptoms, anxiety, depression, cortisol levels and stressful life events during postmenstrual and perimenstrual phases in women with perimenstrual turmoil and in asymptomatic women? 3. Are there different patterns of brain function during postmenstrual and perimenstrual phases of the menstrual cycle between women with perimenstrual turmoil and women who are asymptomatic? 4. Are there different patterns of brain function across menstrual cycle phases (postmenstrual and perimenstrual) in women with perimenstrual turmoil and women who are asymptomatic? 5. Is brain function in women with perimenstrual turmoil similar to or differently organized from neurometrically established patterns for women with Psychiatric Major Affective Disorder? 6. Can subtypes of perimenstrual turmoil be differentiated based on patterns of brain function through the use of neurometric analysis? The study uses a naturalistic descriptive longitudinal design to assess women who are symptomatic and asymptomatic for perimenstrual turmoil symptoms. Women will be screened for eligibility and placement into symptomatic and asymptomatic groups via a telephone inter-view. Approximately 500 eligible participants will complete a daily health diary for three complete menstrual cycles for confirmation of group placement. A final sample for 250 participants (125 symptomatic and 125 asymptomatic) will be followed closely during a complete menstrual cycle. Measures of depression, anxiety, cortisol and progesterone levels, and life stress events will be taken 1 to 2 times weekly along with daily perceptions of symptoms.. These measures will also be obtained between 7-10 days postmenstrually and between -3 to +2 days perimenstrually along with QEEG measurement. A combination of Chi-square, stepwide multiple regression and analysis of covariance will be used to address the research questions.

本研究的目的是：（a）描述，比较和对比 大脑功能的模式，通过使用神经测量分析， 有围绝经期紊乱症状的女性和无或轻度 围绝经期症状，和;（B）确定以下模式的关联： 大脑功能与围绝经期症状，焦虑，抑郁，和 皮质醇水平在月经后期和围月经期之间的 有症状和无症状的女性。 以下研究问题 将被调查：1。患有围绝经期紊乱的女性是否有 精神病理学的发病率比无症状的女性高吗？2.有没有 大脑功能和围绝经期症状之间的关系， 焦虑，抑郁，皮质醇水平和紧张的生活事件， 围月经期妇女的经后和围月经期 和无症状女性中的感染3.是否有不同的模式 月经后期和月经期的脑功能 月经周期与围月经期紊乱的妇女和 没有症状吗4.大脑的功能是否有不同的模式 女性月经周期各阶段（经后和围月经期） 和无症状的女性5.是脑 功能在围绝经期紊乱的女性中与 根据神经测量学建立的女性模式组织， 精神严重情感障碍？6.脑膜周围炎的Can亚型 根据大脑功能的模式， 使用神经测量分析这项研究使用了自然主义的描述性方法， 评估有症状和无症状女性的纵向设计 治疗围绝经期紊乱症状 女性将接受筛查， 合格性和安置到有症状和无症状的群体，通过 电话采访。 大约500名合格的参与者将 完成三个完整月经周期的每日健康日记， 确认组的位置。 250名参与者的最终样本 (125有症状和125无症状），将密切跟踪期间， 完整的月经周期 抑郁、焦虑、皮质醇和 孕激素水平，生活压力事件将采取1至2次 每周沿着症状的日常感知。 这些措施将 也可以在产后7-10天和-3至+2天之间获得 围月经期沿着天进行QEEG测量。 的组合 卡方，逐步多元回归和协方差分析将 用于解决研究问题。