DEPRESSION RISK, INFANT-MOTHER ATTACHMENT AND CORTISOL

抑郁风险、母婴依恋和皮质醇

• 批准号: 7376544
• 负责人: Delia M Vazquez
• 金额: $ 7万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376544
• 关键词: cortisol; depression; emotions; parents

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in studying mothers that are at risk for depression and their interaction with their infants during the first 14 months of life. The reason that we are interested in this topic is that over the last decade a number of long-term studies have confirmed that children of affectively ill parents are at a greater risk for psychiatric disorders than children from homes with unaffected parents. Although a genetic predisposition is clearly evident in these individuals, social, familial and environmental factors are also strong predictors. In particular, the impact of maternal depression on the initiation of this process may be substantial, as depression affects many facets of communication in the maternal-infant unit. Rate of speech, voice quality, eye-to-eye contact and behavioral responsiveness are core aspects of the mother-infant relationship which develop early in life and are affected by depression. Although these changes in the mother's behavior may appear to be subtle they interfere with the facilitation of the infant's neurological, motor and social development. Therefore a portion of this project focuses on observing and recording (through self-report) mothers' feelings and interactions with their babies during periodically scheduled home visits. Another portion of this study focuses on determining how stress related hormones which have been linked to depression may change overtime as the mother progresses through her pregnancy, at birth and in both mother and infant, as the maternal-infant relationship matures. The purpose is to better understand the role of early development of these hormones on the evolution of depressive disorders. Identifying behaviors, abnormal hormonal function and its temporal relationships early in life will allow for early intervention strategies that may be beneficial for both mother's affect and the infant's physical and emotional development.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们感兴趣的是研究那些有抑郁风险的母亲，以及她们在婴儿出生后的前14个月里与婴儿的互动。我们对这个话题感兴趣的原因是，在过去的十年里，许多长期研究已经证实，父母患有情感疾病的孩子比父母没有情感疾病的孩子患精神疾病的风险更大。虽然遗传倾向在这些人身上很明显，但社会、家庭和环境因素也是强有力的预测因素。特别是，母亲抑郁对这一过程开始的影响可能是实质性的，因为抑郁影响母婴单位中沟通的许多方面。语速、语音质量、眼神交流和行为反应是母婴关系的核心方面，这些方面在生命早期发展，并受到抑郁症的影响。虽然母亲行为上的这些变化可能看起来很微妙，但它们会干扰婴儿神经、运动和社会发展的促进。因此，这个项目的一部分重点是观察和记录（通过自我报告）母亲在定期安排的家访中与婴儿的感受和互动。这项研究的另一部分侧重于确定与抑郁有关的压力相关激素如何随着母亲在怀孕、分娩、母婴关系成熟的过程中发生变化。目的是为了更好地了解这些激素的早期发育在抑郁症演变中的作用。在生命早期识别行为，异常激素功能及其时间关系将允许早期干预策略，这可能对母亲的影响和婴儿的身体和情感发展都有益。