COMPUTER METHODS FOR PHYSIOLOGICAL PROBLEMS

(1)纤毛中波传播的模拟 这一部分的目标包括推导平面滑动细丝 根据轴丝三维结构的规范而建立的模型 最终，结合了动态跨桥的逼真模型 周而复始。我们还将构建钙离子控制弯曲的模型。 启蒙和传播，并将把这一点纳入三个 维度系统。 (2)逼真的神经元计算机模型 (A)我们寻求有助于理解神经元中的一些问题 我们觉得很有趣的功能，即模拟信号是如何传输的 沿非棘突的轴突及其末端的传递有何不同 在时相突触。B)另一个问题是获得更多 通过研究时相神经元是如何发挥功能的 脉冲触发的阈值由脉冲的位置和密度来调节 电压敏感通道以及时间和空间突触 总而言之。 (3)生理学的计算机方法和技术 这里的目标是：a)开发在线设置和高效 求解非线性代数方程组以便于 制定有针对性的计划，以处理特定的生理问题 问题；b)开发用于模拟的特殊方法 传播过程。 (4)协作与培训 将与有限的其他研究实验室建立协作 或者没有计算机模拟的经验，以便开发新的 应用程序和培训调查人员的计算机模拟技术。

(1) Modeling of wave propagation in cilia The objectives of this part include deriving the planar sliding filament model from specification of the three dimensional structure of the axoneme and, eventually, incorporating realistic models of the dynein cross bridge cycle. We also will construct a model for calcium controlled bend initiation and propagation and will incorporate this into the three dimensional system. (2) Realistic computer models of neurons (a) We seek to contribute to the understanding of some problems in neuron function which we find intriguing, i.e., how are analog signals transmitted along non-spiking axons and how does transmission at its termination differ from that at phasic synapses. b) Another problem is to gain further insight into the functioning of a phasic neuron by examining how its threshold for impulse initiation is mediated by the location and density of voltage sensitive channels as well as by temporal and spatial synaptic summation. (3) Computer methods and techniques for Physiology Objectives here are: a) the development of online setup and efficient solution of systems of nonlinear algebraic equations in order to facilitate development of targeted programs to deal with specific physiological problems; b) the development of special methods for simulation of propagation processes. (4) Collaboration and Training Collaboration will be established with other research labs having limited or no experience with computer simulations in order to develop new applications and train investigators in computer simulation techniques.