COMPUTER METHODS FOR PHYSIOLOGICAL PROBLEMS

(1)波在纤毛中传播的模拟 这一部分的目的包括推导平面滑动丝 从轴丝的三维结构的规格模型 并最终将动力蛋白跨桥的真实模型 周期 我们也将建立一个钙控弯曲模型 启动和传播，并将其纳入三个 维度系统 (2)神经元的现实计算机模型 (a)我们试图为理解神经元中的一些问题做出贡献。 我们发现有趣的功能，即，模拟信号如何传输 沿着非尖峰轴突的传输以及在其终止处的传输如何不同 从相位突触中分离出来 B）另一个问题是获得进一步的 通过检查其如何影响相位神经元的功能， 脉冲启动的阈值由以下因素的位置和密度介导： 电压敏感通道以及时间和空间突触 求和 (3)生理学计算机方法与技术 这里的目标是：a）在线设置和高效的开发 非线性代数方程组的解，以便于 制定有针对性的方案，以处理特定的生理 问题; B）模拟的特殊方法的发展 传播过程 (4)协作和培训 将与其他研究实验室建立合作， 或者没有计算机模拟的经验， 应用和培训研究人员在计算机模拟技术。

(1) Modeling of wave propagation in cilia The objectives of this part include deriving the planar sliding filament model from specification of the three dimensional structure of the axoneme and, eventually, incorporating realistic models of the dynein cross bridge cycle. We also will construct a model for calcium controlled bend initiation and propagation and will incorporate this into the three dimensional system. (2) Realistic computer models of neurons (a) We seek to contribute to the understanding of some problems in neuron function which we find intriguing, i.e., how are analog signals transmitted along non-spiking axons and how does transmission at its termination differ from that at phasic synapses. b) Another problem is to gain further insight into the functioning of a phasic neuron by examining how its threshold for impulse initiation is mediated by the location and density of voltage sensitive channels as well as by temporal and spatial synaptic summation. (3) Computer methods and techniques for Physiology Objectives here are: a) the development of online setup and efficient solution of systems of nonlinear algebraic equations in order to facilitate development of targeted programs to deal with specific physiological problems; b) the development of special methods for simulation of propagation processes. (4) Collaboration and Training Collaboration will be established with other research labs having limited or no experience with computer simulations in order to develop new applications and train investigators in computer simulation techniques.