LOCAL INTERACTIONS AMONG HIPPOCAMPAL NEURONS
LOCAL INTERACTIONS AMONG HIPPOCAMPAL NEURONS
批准号:
3398940
负责人:
PHILIP A SCHWARTZKROIN
金额:
$17.85万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1983
资助国家:
美国
项目状态:
已结题
起止时间:
1983-01-01 至 1993-12-31
中文摘要
随着现代免疫细胞化学和细胞内化学的发展
英文摘要
With the development of modern immunocytochemical and intracellular
electrophysiological techniques, the complexity of local circuitry in
hippocampus has become apparent. Although the hippocampus is a relatively
simple cortical structure, it is thought to participate in complex
information processing tasks. The diversity of interneuron types, their
transmitters, and their local circuitry must be key elements in providing
the system with the means of modulating the activity of primary projection
cells. In the present application, we continue our study of those
interneurons and local circuitries. Further, we propose to initiate a
series of studies examining the effects of various "traumatic" treatments
on the interneurons of hippocampus, and the consequences of damaging
specific vulnerable cell populations.
The studies will be carried out on parallel, but closely interacting,
tracks. Morphological characterization, by light and electron
n=microscopic/immunocytochemical techniques, will describe the locations,
arborization patterns, and putative neurotransmitter content of specific
interneuron populations in the CA1, CA3, and dentate regions of rat
hippocampus. These studies will also provide guidance for in vitro slice
electrophysiological investigations with will attempt to characterize
interneurons on the basis of their electrophysiological properties and
their synaptic inter-actions with principal cell types (using simultaneous
intracellular recordings of cell pairs). Interneurons will be
intracellularly labeled and examined, in turn, at the morphological level.
The same morphological and electrophysiological techniques will be used to
assess the effects of various treatments on hippocampal interneurons and
interneuron-dependent circuitry. Ischemia, anoxia, and stimulation
treatments will be delivered to intact animals, which will be examined
morphologically, and from which hippocampal slices will be obtained from
electrophysiological investigation. Parallel treatments will be carried
out in slices while recording from suspected vulnerable interneurons.
Procedures will be developed to "protect" vulnerable interneurons from
effects of these treatments.
These studies will provide a descriptive basis for understanding
interneurons and interneuron local circuitry in hippocampus, and will test
a number of specific hypotheses regarding interneuron action in
hippocampus.
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会议论文
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批准号:8051831
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项目类别:
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资助金额:$32.59万
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财政年份:2008
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
Epileptogenic effects of periventricular nodular heterotopia
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批准号:7799888
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项目类别:
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资助金额:$32.92万
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财政年份:2008
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
Epileptogenic effects of periventricular nodular heterotopia
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批准号:7464129
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项目类别:
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资助金额:$32.11万
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财政年份:2008
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
Epileptogenic effects of periventricular nodular heterotopia
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批准号:7563314
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项目类别:
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资助金额:$32.11万
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财政年份:2008
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
Developing a rat model of posttraumatic epilepsy
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批准号:6846023
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项目类别:
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资助金额:$13.74万
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财政年份:2004
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
Seizures and Autism
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批准号:6705104
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项目类别:
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资助金额:$2.6万
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财政年份:2004
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
Developing a rat model of posttraumatic epilepsy
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批准号:6756357
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项目类别:
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资助金额:$20.67万
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财政年份:2004
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
CORE--NEUROSCIENCE
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批准号:6630008
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项目类别:
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资助金额:$8.86万
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财政年份:2002
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
CORE--NEUROSCIENCE
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批准号:6501897
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项目类别:
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资助金额:$8.86万
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财政年份:2001
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
CORE--NEUROSCIENCE
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批准号:6335045
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项目类别:
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资助金额:$28.42万
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财政年份:2000
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
CORE--NEUROSCIENCE
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批准号:6201986
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项目类别:
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资助金额:$28.42万
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财政年份:1999
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
CORE--NEUROSCIENCE CORE
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批准号:6108121
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项目类别:
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资助金额:$23.34万
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财政年份:1998
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
CORE--NEUROSCIENCE CORE
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批准号:6240729
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项目类别:
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资助金额:$21.62万
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财政年份:1997
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
REGULATION OF EXTRACELLULAR SPACE IN EPILEPTOGENESIS
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批准号:2431313
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项目类别:
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资助金额:$24.99万
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财政年份:1996
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
REGULATION OF EXTRACELLULAR SPACE IN EPILEPTOGENESIS
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批准号:2274812
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项目类别:
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资助金额:$26.01万
-
财政年份:1996
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负责人:PHILIP A SCHWARTZKROIN
-
依托单位:
REGULATION OF EXTRACELLULAR SPACE IN EPILEPTOGENESIS
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批准号:2892114
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项目类别:
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资助金额:$24.11万
-
财政年份:1996
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负责人:PHILIP A SCHWARTZKROIN
-
依托单位:
REGULATION OF EXTRACELLULAR SPACE IN EPILEPTOGENESIS
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批准号:6149345
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项目类别:
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资助金额:$4.5万
-
财政年份:1996
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负责人:PHILIP A SCHWARTZKROIN
-
依托单位:
REGULATION OF EXTRACELLULAR SPACE IN EPILEPTOGENESIS
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批准号:2714610
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项目类别:
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资助金额:$23.18万
-
财政年份:1996
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负责人:PHILIP A SCHWARTZKROIN
-
依托单位:
REGULATION OF EXTRACELLULAR SPACE IN EPILEPTOGENESIS
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批准号:6191021
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项目类别:
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资助金额:$1.52万
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财政年份:1996
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负责人:PHILIP A SCHWARTZKROIN
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依托单位:
REGULATION OF EXTRACELLULAR SPACE IN EPILEPTOGENESIS
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批准号:6187323
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项目类别:
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资助金额:$25.07万
-
财政年份:1996
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负责人:PHILIP A SCHWARTZKROIN
-
依托单位:
海外基金