Seizures and Autism

癫痫发作和自闭症

• 批准号: 6705104
• 负责人: PHILIP A SCHWARTZKROIN
• 金额: $ 2.6万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6705104
• 关键词: autism; developmental neurobiology; generalized seizures; meeting /conference /symposium; neurochemistry; travel

DESCRIPTION (provided by applicant): The role of seizure activity as a causal contributor to autism and/or neurological regression (e.g., in language) has been hotly debated. The proposed symposium is designed to explore the evidence for such an association by discussing the data on which these relationships are based, and elucidating potential basic mechanisms that might link such neurological disorders of childhood/development. The meeting will be divided into three major sections: I. Activity-dependent generation of normal brain function during development; II. Neurochemical and electrical correlates of brain developmental abnormalities; and III. Clinical regressive disorders and their relationship to developmental epilepsies. Basic scientists and clinical investigators from a number of different disciplines (epilepsy, autism, sleep) will be invited to participate in the discussion. In addition, we will provide scholarships for young investigators interested in these clinical and basic research issues/relationships. The two-and-a-half day conference is planned for early spring (March) of 2004, in the Sacramento/Lake Tahoe area. The goal of this conference is to define potential (causal?) links between developmental seizure disorders and the occurrence of autistic disorders, particularly behavioral and language regression. We hope to foster a critical discussion regarding common/shared mechanisms. The results of the discussion will be summarized in a "white paper" to be submitted to a neurology/development/epilepsy journal.

描述（由申请人提供）：癫痫发作活动作为自闭症和/或神经退行的因果贡献者的作用（例如，语言上，一直在激烈争论。 拟议的研讨会旨在探讨这种关联的证据，讨论这些关系所依据的数据，并阐明潜在的基本机制，可能会连接这种神经系统疾病的儿童/发展。 会议将分为三个主要部分：一。 发育期间正常脑功能的活动依赖性生成; II. 脑发育异常的神经化学和电相关性;和III. 临床退行性障碍及其与发育性癫痫的关系。 来自不同学科（癫痫，自闭症，睡眠）的基础科学家和临床研究人员将被邀请参加讨论。 此外，我们将为对这些临床和基础研究问题/关系感兴趣的年轻研究人员提供奖学金。 为期两天半的会议计划于2004年早春（3月）在萨克拉门托/太浩湖地区举行。 本次会议的目标是定义潜在的（因果？）发展性癫痫发作障碍与自闭症发生之间的联系，特别是行为和语言退化。 我们希望促进就共同/共享机制进行重要讨论。 讨论结果将总结在一份“白色论文”中，提交给神经学/发育/癫痫杂志。