EPIDEMIOLOGY OF MIGRAINE HEADACHE

偏头痛是一种常见的、反复发作的、严重的、经常使人丧失工作能力的疾病。 据估计，4%-19%的成年男性和8%-29%的成年女性会受到影响。 一项调查显示，严重头痛导致近1000万人 每年的门诊就诊次数。 拟议的两阶段研究的主要目标是：1)确定 偏头痛的流行，2)进一步完善病例的定义 并确定偏头痛亚型的特征，以确定重要的 与偏头痛发生和发展相关的危险因素 社区人群中新发病例中的头痛和4)至 找出导致偏头痛特定发作的事件 在案件中。这些目标将通过一项研究来实现，该研究包括 分两个阶段。首先，我们将进行以人口为基础的患病率调查 在一个特征良好的美国社区。第二，我们将执行一项 220例新发(发)偏头痛病例对照研究 在流行率调查中确定的。 拟议的基于人群的流行率研究将是首批 在美国社区进行；结果可以与 从其他以人群为基础的流行病学研究 英国、以色列和丹麦。在流行中使用的方法 调查将提供一种方法来估计偏头痛的发病率。这 将是独一无二的，因为我们无法找到任何其他 发病率研究。在患病率调查中，最近有过一次 偏头痛的发作将被问及可能诱发的因素 那次袭击。与过去的一些研究相比，这项研究将 为可能的沉淀物提供更可靠的数据。最后，一个 使用最近发病病例的病例对照研究应该使我们能够专注于 由先前的工作提出的关于风险因素的更具体的假设， 包括压力、心理社会和个性因素；激素因素 女性；以及家庭因素。

Migraine headache is a common, recurrent, severe and often incapacitating condition estimated to affect 4-19% of adult men and 8-29% of adult women. One survey showed that severe headache is responsible for almost 10 million outpatient visits to physicians per year. The primary objectives of the proposed two-phase study are 1) to determine the prevalence of migraine, 2) to further refine the definition of a case of migraine and to characterize migraine subtypes 3) to identify important risk factors associated with the development and onset of migraine headaches in recent-onset cases in a community population and 4) to identify events which precipitate specific episodes of migraine headache among cases. These objectives will be accomplished by a study consisting of two phases. First, we will conduct a population-based prevalence survey in a well-characterized American community. Second, we will perform a case-control study using 220 recent-onset (incident) migraine cases identified in the prevalence survey. The proposed population-based prevalence study would be one of the first to be carried out in an American community; results could be compared to those from other population-based epidemiologic studies carried out in Great-Britain, Israel and Denmark. The methods used in the prevalence survey will provide a means to estimate the incidence of migraine. This would be unique in that we have been unable to find reports of any other incidence study. In the prevalence survey subjects who have had a recent attack of migraine will be asked about factors which may have precipitated the attack. In contrast to a number of past studies, this study will provide more reliable data on possible precipitants. Finally, a case-control study using recent-onset cases should allow us to focus on more specific hypotheses regarding risk factors suggested by previous work, including stress, psychosocial and personality factors; hormonal factors in women; and familial factors.