EPIDEMIOLOGY OF MIGRAINE HEADACHE

偏头痛是一种常见的，反复发作的，严重的，往往使人丧失能力， 估计影响4-19%的成年男性和8-29%的成年女性。 一项调查显示，严重的头痛是近1000万人 每年的门诊医生。 拟议的两阶段研究的主要目标是：1）确定 偏头痛的患病率，2）进一步细化病例定义 偏头痛和偏头痛亚型的特点3），以确定重要的 与偏头痛发生和发作相关的危险因素 在社区人群中新发头痛病例和4） 确定促使偏头痛特定发作的事件 在案件中。 这些目标将通过一项研究来实现， 两个阶段。 首先，我们会进行以人口为基础的患病率调查 在一个特征鲜明的美国社区。 第二，我们将执行一个 220例新发偏头痛病例对照研究 在流行病学调查中发现。 拟议的基于人口的流行率研究将是第一个 在美国社区进行;结果可以与那些 从其他基于人群的流行病学研究中， 英国、以色列和丹麦。 流行病中使用的方法 调查将提供一种手段来估计偏头痛的发病率。 这 是独一无二的，因为我们无法找到任何其他的报告， 发病率研究 在患病率调查中， 偏头痛发作时会被问及可能导致偏头痛的因素 袭击 与以往的一些研究相比，本研究将 为可能的沉淀物提供更可靠的数据。 最后 使用近期发病病例的病例对照研究应使我们能够关注 关于先前工作提出的风险因素的更具体的假设， 包括压力、心理社会和个性因素; 妇女;家庭因素。

Migraine headache is a common, recurrent, severe and often incapacitating condition estimated to affect 4-19% of adult men and 8-29% of adult women. One survey showed that severe headache is responsible for almost 10 million outpatient visits to physicians per year. The primary objectives of the proposed two-phase study are 1) to determine the prevalence of migraine, 2) to further refine the definition of a case of migraine and to characterize migraine subtypes 3) to identify important risk factors associated with the development and onset of migraine headaches in recent-onset cases in a community population and 4) to identify events which precipitate specific episodes of migraine headache among cases. These objectives will be accomplished by a study consisting of two phases. First, we will conduct a population-based prevalence survey in a well-characterized American community. Second, we will perform a case-control study using 220 recent-onset (incident) migraine cases identified in the prevalence survey. The proposed population-based prevalence study would be one of the first to be carried out in an American community; results could be compared to those from other population-based epidemiologic studies carried out in Great-Britain, Israel and Denmark. The methods used in the prevalence survey will provide a means to estimate the incidence of migraine. This would be unique in that we have been unable to find reports of any other incidence study. In the prevalence survey subjects who have had a recent attack of migraine will be asked about factors which may have precipitated the attack. In contrast to a number of past studies, this study will provide more reliable data on possible precipitants. Finally, a case-control study using recent-onset cases should allow us to focus on more specific hypotheses regarding risk factors suggested by previous work, including stress, psychosocial and personality factors; hormonal factors in women; and familial factors.