SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTER

亚临床心血管疾病研究中心

• 批准号: 6359444
• 负责人: MOYSES A SZKLO
• 金额: $ 35.52万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2009-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359444
• 关键词: African American; Chinese American; Hispanic Americans; atherosclerosis; cardiovascular disorder epidemiology; caucasian American; clinical research; coronary disorder; disease /disorder proneness /risk; early diagnosis; human middle age (35-64); human old age (65+); human subject; mass screening; noninvasive diagnosis; prognosis; racial /ethnic difference

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84. Approximately 40 percent of the cohort will be white, 30 percent African-American, 20 percent Hispanic, and 10 percent Chinese-American. The cohort will be recruited from six Field Centers and characterized with respect to a variety of subclinical cardiovascular disease measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for case-control studies. DNA will be extracted and lymphocytes immortalized for study of candidate genes and possibly genome-wide scanning. Four clinical examinations, 18-24 months apart, are planned. Participants will be followed for identification and characterization of cardiovascular disease events and interventions received.

梅萨是一项为期10年的亚临床心血管疾病（在产生临床体征和症状之前以非侵入性方式检测到的疾病）特征和风险因素的观察性研究，这些风险因素可预测临床上明显的心血管疾病的进展，并预测亚临床疾病本身的进展，在6，500名45-84岁男性和女性的多样化和代表性人群样本中进行。大约40%的人群将是白色，30%的非洲裔美国人，20%的西班牙裔美国人和10%的华裔美国人。 该队列将从6个现场中心招募，并在各种亚临床心血管疾病指标、标准冠状动脉风险因素、社会人口因素、生活方式因素和心理社会因素方面进行表征。 将对血液样本进行推定生化风险因素分析，并储存用于病例对照研究。 将提取DNA并使淋巴细胞永生化，用于候选基因的研究和可能的全基因组扫描。 计划进行四次临床检查，间隔18-24个月。将对受试者进行随访，以识别和描述心血管疾病事件和接受的干预措施。

项目成果

Individual pathogens, pathogen burden and markers of subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis.

亚临床动脉粥样硬化的个体病原体、病原体负荷和标志物：动脉粥样硬化的多种族研究。

• DOI: 10.2459/jcm.0b013e32832cacab
• 发表时间: 2009
• 期刊: Journal of cardiovascular medicine (Hagerstown, Md.)
• 作者: Szklo,Moyses;Ding,Jingzhong;Tsai,MichaelY;Cushman,Mary;Polak,JosephF;Lima,João;Barr,RGraham;Sharrett,ARichey
• 通讯作者: Sharrett,ARichey

Assessment of in-stent restenosis using 64-MDCT: analysis of the CORE-64 Multicenter International Trial.

使用 64-MDCT 评估支架内再狭窄：CORE-64 多中心国际试验分析。

• DOI: 10.2214/ajr.09.2652
• 发表时间: 2010
• 期刊: AJR. American journal of roentgenology
• 作者: Wykrzykowska,JoannaJ;Arbab-Zadeh,Armin;Godoy,Gustavo;Miller,JulieM;Lin,Shezhang;Vavere,Andrea;Paul,Narinder;Niinuma,Hiroyuki;Hoe,John;Brinker,Jeffrey;Khosa,Faisal;Sarwar,Sheryar;Lima,Joao;Clouse,MelvinE
• 通讯作者: Clouse,MelvinE

Association of endogenous sex hormone levels with coronary artery calcium progression among post-menopausal women in the Multi-Ethnic Study of Atherosclerosis (MESA).

• DOI: 10.1016/j.jcct.2018.09.010
• 发表时间: 2019-01
• 期刊: Journal of cardiovascular computed tomography
• 影响因子: 5.4
• 作者: Subramanya V;Zhao D;Ouyang P;Ying W;Vaidya D;Ndumele CE;Heckbert SR;Budoff MJ;Post WS;Michos ED
• 通讯作者: Michos ED

Endogenous Sex Hormones and Incident Cardiovascular Disease in Post-Menopausal Women.

• DOI: 10.1016/j.jacc.2018.01.083
• 发表时间: 2018-06-05
• 期刊: Journal of the American College of Cardiology
• 影响因子: 24
• 作者: Zhao D;Guallar E;Ouyang P;Subramanya V;Vaidya D;Ndumele CE;Lima JA;Allison MA;Shah SJ;Bertoni AG;Budoff MJ;Post WS;Michos ED
• 通讯作者: Michos ED

Accuracy of multidetector computed tomography for detection of coronary artery stenosis in acute coronary syndrome compared with stable coronary disease: a CORE64 multicenter trial substudy.

与稳定冠心病相比，多排计算机断层扫描检测急性冠脉综合征冠状动脉狭窄的准确性：CORE64 多中心试验亚组研究。

• DOI: 10.1016/j.ijcard.2014.08.130
• 发表时间: 2014
• 期刊: International journal of cardiology
• 影响因子: 3.5
• 作者: Sara,Leonardo;Rochitte,CarlosE;Lemos,PedroA;Niinuma,Hiroyuki;Dewey,Marc;Shapiro,EdwardP;Gottlieb,Ilan;Mansur,AntônioP;Nicolau,JoséC;Lardo,AlbertC;Azevedo,ClerioF;Kalil-Filho,Roberto;Vavere,AndreaL;Cohn,Silvia;Cox,Chris
• 通讯作者: Cox,Chris