SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTER

亚临床心血管疾病研究中心

• 批准号: 6019927
• 负责人: MOYSES A SZKLO
• 金额: $ 22.31万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2009-01-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6019927
• 关键词: African American; Chinese American; Hispanic Americans; atherosclerosis; cardiovascular disorder epidemiology; caucasian American; clinical research; coronary disorder; disease /disorder proneness /risk; early diagnosis; human middle age (35-64); human old age (65+); human subject; mass screening; noninvasive diagnosis; prognosis; racial /ethnic difference

MESA is a 10-year observational study of the characteristics of subclinical cardiovascular disease (disease detected non-invasively before it has produced clinical signs and symptoms) and risk factors that predict progression to clinically overt cardiovascular disease and that predict progression of subclinical disease itself, in a diverse and representative population-based sample of 6,500 men and women aged 45-84. Approximately 40 percent of the cohort will be white, 30 percent African-American, 20 percent Hispanic, and 10 percent Chinese-American. The cohort will be recruited from six Field Centers and characterized with respect to a variety of subclinical cardiovascular disease measures, standard coronary risk factors, sociodemographic factors, lifestyle factors, and psychosocial factors. Blood samples will be assayed for putative biochemical risk factors and stored for case-control studies. DNA will be extracted and lymphocytes immortalized for study of candidate genes and possibly genome-wide scanning. Four clinical examinations, 18-24 months apart, are planned. Participants will be followed for identification and characterization of cardiovascular disease events and interventions received.

MESA是一项为期10年的观察性研究，研究亚临床心血管疾病（在产生临床体征和症状之前非侵入性检测到的疾病）的特征和预测临床显性心血管疾病进展的风险因素，以及预测亚临床疾病本身进展的风险因素，研究对象是6500名年龄在45-84岁之间的具有代表性的人群样本。大约40%的学生将是白人，30%是非裔美国人，20%是西班牙裔，10%是华裔。该队列将从六个领域中心招募，并以各种亚临床心血管疾病测量、标准冠状动脉危险因素、社会人口因素、生活方式因素和心理社会因素为特征。血液样本将被分析推定的生化危险因素，并保存以供病例对照研究。DNA将被提取，淋巴细胞将被永生化，用于候选基因的研究和可能的全基因组扫描。计划进行4次临床检查，间隔18-24个月。将对参与者进行随访，以确定和描述心血管疾病事件和所接受的干预措施。