THE NEURAL BASIS OF INTERNAL REPRESENTATION OF PLACE

这个项目的目标是了解神经 内部表征形成的机制 地点，以及指南中这些表述的联系 空间导航。正在考虑的主要假设 是地方学习涉及到形成内部的 链接有关给定位置的信息的转移矩阵 具有移动信息以便重建，通过 联想回忆，对应目标的一种表征 地点。给出了神经网络的最小模型。 这一计算方案的实施，它描述了 长时程突触增强的联想特性 可以用来完成这项任务。全文共分四个部分 所提议的项目。首先是对 大鼠大脑皮层空间和运动表征的性质 汇聚在海马体结构上的区域。我们会 应用一种新的神经生理学技术，它允许 记录和分析几个人的行为相关性 在同一时间内的单个单元。我们还将进一步探索 齿状回神经元活动与空间记忆的关系 和/或根据调查结果作出的决策 上一个支持期。这将在两个不同的地方进行 将单单元记录与分析相结合的研究 突触效能和/或突触后兴奋性的变化 在空间“工作”记忆过程中。最后，我们将分析 长时程突触增强在控制突触功能中的特殊作用 在大鼠海马区定位特异性神经元放电 在空间记忆问题期间自由移动的老鼠。后者 研究应澄清“硬连线”的相对重要性 与突触增益在这一过程中的调制 刺激驱动和记忆驱动的空间定向。 整个项目预计将提供数据，有助于 脑机制通用模型的构建 潜在的更复杂但相似的信息类型 在人类中发现的加工过程，其特征是 在动作和它们的动作之间形成条件关联 不同背景下的后果。

The objective of this project is an understanding of the neural mechanism underlying the formation of internal representations of places, and the linkage of these representations in the guidance of spatial navigation. The primary hypothesis under consideration is that place learning involves the formation of an internal transition matrix which links information about a given location with movement information in order to reconstruct, by associative recall, a representation of the corresponding target location. A minimal model is presented for the neural implementation of this computational scheme, which describes how the associative property of long-term synaptic enhancement could be used to accomplish this task. There are four main parts to the proposed project. First will be an investigation of the nature of the spatial and movement representations in rat cortical areas which converge on the hippocampal formation. We will apply a novel neurophysiological technique, which permits the recording and analysis of the behavioral correlates of several single units at the same time. We will also explore further the relation of dentate gyrus neuronal activity to spatial memory and/or decision making which is suggested by the results of the previous support period. This will be carried out in two different studies which will combine single unit recording and the analysis of changes in synaptic efficacy and/or post-synaptic excitability during spatial "working" memory. Finally, we will analyze the specific role of long-term synaptic enhancement in the control of place specific neuronal discharge in the hippocampal formation of freely moving rats during a spatial memory problem. The latter study should clarify the relative importance of "hard wiring" versus modulation of synaptic gain in this process during both stimulus-driven, and memory-driven spatial orientation. The overall project is expected to provide data which will aid in the construction of a general model for the brain mechanisms underlying more complex, but analogous, types of information processing found in humans, and which are characterized by the formation of conditional associations between actions and their consequences under different contexts.