THE NEURAL BASIS OF INTERNAL REPRESENTATION OF PLACE

地点内部表征的神经基础

• 批准号: 3400631
• 负责人: BRUCE L MCNAUGHTON
• 金额: $ 13.66万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-03-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3400631
• 关键词: cognition; decision making; discrimination learning; electroencephalography; evoked potentials; hippocampus; laboratory rat; memory; microelectrodes; neural information processing; neuromuscular system; neurophysiology; neuropsychology; orientation; single cell analysis; space perception

The objective of this project is an understanding of the neural mechanism underlying the formation of internal representations of places, and the linkage of these representations in the guidance of spatial navigation. The primary hypothesis under consideration is that place learning involves the formation of an internal transition matrix which links information about a given location with movement information in order to reconstruct, by associative recall, a representation of the corresponding target location. A minimal model is presented for the neural implementation of this computational scheme, which describes how the associative property of long-term synaptic enhancement could be used to accomplish this task. There are four main parts to the proposed project. First will be an investigation of the nature of the spatial and movement representations in rat cortical areas which converge on the hippocampal formation. We will apply a novel neurophysiological technique, which permits the recording and analysis of the behavioral correlates of several single units at the same time. We will also explore further the relation of dentate gyrus neuronal activity to spatial memory and/or decision making which is suggested by the results of the previous support period. This will be carried out in two different studies which will combine single unit recording and the analysis of changes in synaptic efficacy and/or post-synaptic excitability during spatial "working" memory. Finally, we will analyze the specific role of long-term synaptic enhancement in the control of place specific neuronal discharge in the hippocampal formation of freely moving rats during a spatial memory problem. The latter study should clarify the relative importance of "hard wiring" versus modulation of synaptic gain in this process during both stimulus-driven, and memory-driven spatial orientation. The overall project is expected to provide data which will aid in the construction of a general model for the brain mechanisms underlying more complex, but analogous, types of information processing found in humans, and which are characterized by the formation of conditional associations between actions and their consequences under different contexts.

这个项目的目的是了解神经 内在表征形成的机制 的地方，以及这些代表性的联系，在指导 空间导航。 考虑中的主要假设 地方学习涉及到一种内在的 将给定位置的信息链接起来的转移矩阵 与运动信息，以便重建，通过 联想回忆，一种对应目标的表征， 位置. 提出了一种神经网络的最小模型， 该计算方案的实施，其描述了 长时程突触增强的关联性 可以用来完成这项任务。 主要有四个部分 到拟议的项目。 首先将是一个调查的 大鼠皮层空间和运动表征的性质 聚集在海马结构上的区域。 我们将 应用一种新的神经生理技术，允许 记录和分析几个行为相关性 单位与此同时 我们亦会进一步探讨 齿状回神经元活动与空间记忆的关系 和/或决策的结果所建议的 前一个支持期。 这将在两个不同的 将联合收割机单个装置记录和分析相结合的研究 突触效能和/或突触后兴奋性的变化 在空间“工作”记忆中。 最后，我们将分析 长期突触增强在控制 在海马结构中放置特定的神经元放电 在空间记忆问题中自由移动的老鼠。 后者 研究应澄清“硬接线”的相对重要性 与突触增益的调制在这一过程中， 刺激驱动和记忆驱动的空间定向。 整个项目预计将提供数据， 脑机制的一般模型的构建 更复杂但类似的信息类型 在人类中发现的加工过程，其特征在于 行为与其行为之间的条件关联的形成 不同背景下的后果。