BRAIN EXTRACTION AND BLOOD FLOW WITH THE 123-I AMINES
BRAIN EXTRACTION AND BLOOD FLOW WITH THE 123-I AMINES
批准号:
3401162
负责人:
JOEL H GREENBERG
金额:
$13.51万
依托单位国家:
美国
项目类别:
财政年份:
1984
资助国家:
美国
项目状态:
已结题
起止时间:
1984-12-01 至 1987-11-30
中文摘要
最近,n -异丙基- p -123 i -碘安非他明(123I-IMP)
英文摘要
Recently, the 123I-amines, N-isopropyl-P-123 I-iodoamphetamine (123I-IMP)
and
N,N,N'-Trimethyl-N'-(2-hydroxy-3-methyl-5-123I-iodobenzyl)-1,3-prpanediamine
(123I-HIPDM) have been proposed as agents for the measurement of cerebral
blood flow in pathology. In this proposal we wish to study the
relationship between the distribution of these 123I-amines in various
conditions to ascertain whether they can be used as quantitative indicators
of cerebral blood flow and to study the mechanism of brain uptake and
retention. These new agents have potential use both in the study of many
pathological conditions, both in animal models using autoradiography and in
humans using single photon emission tomography (SPECT). To use these
indicators with autoradiography in animals and with SPECT in humans, we
propose to extend the measurement interval from 30 sec or 5 min. We also
propose to compare these two 123I-amines in pathological conditions to
evaluate their usefulness as CBF agents in human pathology. The brain
extraction and blood flow will be determined under conditions of varying
arterial pH and amine specific activity to evaluate the mechanism of bran
uptake and retention.
The techniques needed for this study have been developed in this laboratory
and involve the use of 123I and 14C labeled tracers using quantitative
double radionuclide autoradiography. The direct evaluation of the
123I-amines distribution will be compared to CB1, as measured with the
established CBF tracer, 14C-iodoantipyrine on a highly regional basis. The
mechanism of 123I-amines brain uptake and retention is not known exactly,
but has been proposed to be due to either their high lipid solubility,
their interaction with nonspecific amine binding situes, or some influence
exerted by the pH gradient across the brain blood barrier.
The study of the behavior of these 123I-amines during stroke, epilepsy, in
the ibotenic acid lesion model, and as a function of pH and amine specific
activity will define the brain uptake mechanism and usefulness of the I-123
amines as CBF tracers.
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Functional activation during cerebral ischemia
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批准号:7460431
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项目类别:
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资助金额:$34.45万
-
财政年份:2008
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负责人:JOEL H GREENBERG
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依托单位:
Functional activation during cerebral ischemia
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批准号:7561045
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项目类别:
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资助金额:$34.45万
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财政年份:2008
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负责人:JOEL H GREENBERG
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依托单位:
Functional activation during cerebral ischemia
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批准号:7772310
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项目类别:
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资助金额:$34.11万
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财政年份:2008
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负责人:JOEL H GREENBERG
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依托单位:
Functional activation during cerebral ischemia
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批准号:8100785
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项目类别:
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资助金额:$6.65万
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财政年份:2008
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负责人:JOEL H GREENBERG
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依托单位:
ROLE OF NITRIC OXIDE IN FUNCTIONAL PLASTICITY
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批准号:6336898
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项目类别:
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资助金额:$1.29万
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财政年份:1998
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负责人:JOEL H GREENBERG
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依托单位:
ISCHEMIA
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批准号:6336897
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项目类别:
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资助金额:$1.29万
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财政年份:1998
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负责人:JOEL H GREENBERG
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依托单位:
ROLE OF NITRIC OXIDE IN FUNCTIONAL PLASTICITY
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批准号:6251561
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项目类别:
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资助金额:$1.29万
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财政年份:1997
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负责人:JOEL H GREENBERG
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依托单位:
ISCHEMIA
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批准号:6251560
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项目类别:
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资助金额:$1.29万
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财政年份:1997
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负责人:JOEL H GREENBERG
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依托单位:
Ischemia Induced Plasticity - Implications for Therapy
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批准号:6780361
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项目类别:
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资助金额:$30.12万
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财政年份:1995
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负责人:JOEL H GREENBERG
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依托单位:
NITRIC OXIDE IN FOCAL CEREBRAL ISCHEMIA
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批准号:2269982
-
项目类别:
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资助金额:$22.95万
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财政年份:1995
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负责人:JOEL H GREENBERG
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依托单位:
Ischemia Induced Plasticity - Implications for Therapy
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批准号:6927045
-
项目类别:
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资助金额:$30.12万
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财政年份:1995
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负责人:JOEL H GREENBERG
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依托单位:
Ischemia Induced Plasticity - Implications for Therapy
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批准号:6640127
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项目类别:
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资助金额:$30.12万
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财政年份:1995
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负责人:JOEL H GREENBERG
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依托单位:
NITRIC OXIDE AND FUNCTIONAL PLASTICITY
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批准号:2272779
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项目类别:
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资助金额:$25.67万
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财政年份:1995
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负责人:JOEL H GREENBERG
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依托单位:
NITRIC OXIDE IN FOCAL CEREBRAL ISCHEMIA
-
批准号:2269983
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项目类别:
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资助金额:$22.86万
-
财政年份:1995
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负责人:JOEL H GREENBERG
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依托单位:
ACTIVATION IN STROKE--IMPLICATIONS FOR REHABILITATION
-
批准号:6393701
-
项目类别:
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资助金额:$33.8万
-
财政年份:1995
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负责人:JOEL H GREENBERG
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依托单位:
NITRIC OXIDE AND FUNCTIONAL PLASTICITY
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批准号:2460601
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项目类别:
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资助金额:$26.65万
-
财政年份:1995
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负责人:JOEL H GREENBERG
-
依托单位:
NITRIC OXIDE IN FOCAL CEREBRAL ISCHEMIA
-
批准号:2460560
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项目类别:
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资助金额:$23.78万
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财政年份:1995
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负责人:JOEL H GREENBERG
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依托单位:
ACTIVATION IN STROKE--IMPLICATIONS FOR REHABILITATION
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批准号:2901441
-
项目类别:
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资助金额:$32.52万
-
财政年份:1995
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负责人:JOEL H GREENBERG
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依托单位:
Ischemia Induced Plasticity - Implications for Therapy
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批准号:6542561
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项目类别:
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资助金额:$29.3万
-
财政年份:1995
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负责人:JOEL H GREENBERG
-
依托单位:
ACTIVATION IN STROKE--IMPLICATIONS FOR REHABILITATION
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批准号:6187958
-
项目类别:
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资助金额:$33.23万
-
财政年份:1995
-
负责人:JOEL H GREENBERG
-
依托单位:
海外基金