HINDBRAIN CONTROL OF INGESTION

控制食物的选择和摄取对 人类和动物健康。发生摄取控制的紊乱 在许多人类疾病中，可能对某些人是致病的。大脑是 最终负责控制食物摄入量。尽管如此， 前脑是大脑中唯一控制摄取的区域 经过广泛的研究。这项工作的总体目标是更好地理解 大脑最尾部(后脑)在控制 摄取。该提案的重点是了解该地区的作用 最后核和邻近孤立核在摄食控制中。 具体地说，提出的实验将1)确定哪种神经 这一地区的联系负责个人的摄取 损伤最后区和孤束核后的变化 2)尝试识别化学上离散的神经元群 调节大脑这一区域对食物摄入量的影响。这些研究 将是最早分析后脑在控制中的作用的人之一 饥饿和食欲。这样的分析很重要，因为一些 食欲的控制似乎来自后脑和所有的控制 食欲必须通过后脑来执行。

The controls of food selection and ingestion are of major importance to human and animal health. Disturbances of the controls of ingestion occur in many human illnesses and may be pathogenic for some. The brain is ultimately responsible for controlling food intake. Nevertheless, the forebrain is the only brain area where control of ingestion has been studied extensively. The overall goal of this work is to better understand the roles of the most caudal part of the brain (hindbrain) in control of ingestion. The proposal focuses on understanding the role of the area postrema and adjacent solitary nucleus in the control of ingestion. Specifically, the experiments proposed will 1) determine which neural connections of this region are responsible for the individual ingestive changes observed after damage to the area postrema and solitary nucleus and 2) attempt to identify chemically discrete neuronal populations which mediate the effects of this brain region on food intake. These studies will be among the first to analyze the role of the hindbrain in the control of hunger and appetite. Such an analysis is important because some controls of appetite seem to arise from the hindbrain and all controls of appetite must be executed via the hindbrain.