HINDBRAIN CONTROL OF INGESTION

控制食物的选择和摄入对于 人类和动物健康。 出现摄食控制紊乱 在许多人类疾病中可能是致病的。 大脑是 最终负责控制食物摄入。 但 前脑是唯一控制摄食的脑区， 广泛研究。 这项工作的总体目标是更好地了解 大脑最尾部（后脑）在控制 摄入 该提案的重点是了解该地区的作用 最后核和邻近的孤核参与摄食的控制。 具体来说，提出的实验将1）确定哪种神经元 该区域的连接负责个体的摄食 损伤最后区和孤束核后观察到的变化， 2)试图识别化学上离散的神经元群体， 调节这个大脑区域对食物摄入的影响。 这些研究 将是第一个分析后脑在控制中的作用的人。 饥饿和食欲。 这样的分析很重要，因为 食欲的控制似乎来自于后脑，而所有对食欲的控制似乎都来自于后脑。 食欲必须通过后脑执行。

The controls of food selection and ingestion are of major importance to human and animal health. Disturbances of the controls of ingestion occur in many human illnesses and may be pathogenic for some. The brain is ultimately responsible for controlling food intake. Nevertheless, the forebrain is the only brain area where control of ingestion has been studied extensively. The overall goal of this work is to better understand the roles of the most caudal part of the brain (hindbrain) in control of ingestion. The proposal focuses on understanding the role of the area postrema and adjacent solitary nucleus in the control of ingestion. Specifically, the experiments proposed will 1) determine which neural connections of this region are responsible for the individual ingestive changes observed after damage to the area postrema and solitary nucleus and 2) attempt to identify chemically discrete neuronal populations which mediate the effects of this brain region on food intake. These studies will be among the first to analyze the role of the hindbrain in the control of hunger and appetite. Such an analysis is important because some controls of appetite seem to arise from the hindbrain and all controls of appetite must be executed via the hindbrain.