ETHANOL AND INTESTINAL CONTROLS OF FOOD INTAKE

乙醇和肠道对食物摄入的控制

• 批准号: 3421989
• 负责人: Robert C Ritter
• 金额: $ 3.51万
• 依托单位: WASHINGTON STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-29 至 1991-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3421989
• 关键词: alcoholic beverage consumption; anorexic agent; biological information processing; cholecystokinin; eating; ethanol; hormone receptor; intestinal mucosa; laboratory rat; neural information processing; nutrient interaction; nutrition related tag; satiations; small intestines; visceral afferent nerve

Although ethanol is a drug with significant effects in virtually all physiological systems, it is also a source of calories. Its voluntary consumption could, therefore, be considered eating. consequently, investigations into the interaction of alcohol with the controls of food intake may provide important information concerning the control of ethanol ingestion. Convincing experimental evidence indicates that the small intestine, its innervation and endocrine cells, play an important role in the control of food intake. For example, the termination of ingestion is mediated in part by the detection of specific nutrients in the small intestine. Furthermore, nutrients in the small intestine release gastrointestinal hormones which appear to be involved in the reduction of food intake. The potential interaction of ethanol with gastrointestinal controls of food intake has not been explored. The goal of the work proposed in this application is to determine whether intestinal controls of food intake are influenced by ethanol and whether these controls may be involved in the control of ethanol intake.

尽管乙醇是一种对几乎所有人都有显著影响的药物 在生理系统中，它也是卡路里的来源。它是自愿的 因此，消费可以被认为是进食。因此， 酒精与食品控制相互作用的研究 摄入量可能提供有关乙醇控制的重要信息 摄取。 令人信服的实验证据表明，小肠，其 神经支配和内分泌细胞在控制血管紧张素转换酶活性中起重要作用。 食物摄入量。例如，摄取的终止在一定程度上是通过 通过检测小肠中的特定营养物质。此外， 小肠中的营养物质释放胃肠激素， 似乎与食物摄入量的减少有关。潜力 乙醇与胃肠控制食物摄入量的相互作用 没有被探索过。本申请中提出的工作的目标是 确定食物摄入量的肠道控制是否受 乙醇以及这些控制措施是否可能参与控制 酒精摄入量。