How the immune system recognises vitamin B-based allergies

免疫系统如何识别基于维生素 B 的过敏

• 批准号: FT160100083
• 负责人: A/Prof Alexandra Corbett
• 金额: $ 47.65万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-10-19
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT160100083
• 关键词: How; immune; system; recognises; vitamin

This project aims to evaluate the range of molecules that can stimulate vitamin B-reactive T cells in mammals and amphibians, and the degree of conservation or variation in these molecules among diverse microorganisms. T cells are immune cells that recognise foreign molecules, including peptides, lipids and vitamin B metabolites, bound to specialised antigen-presenting molecules. In mammals, Mucosal Associated Invariant T cells, still poorly understood, recognise Vitamin B-based molecules. Combining immunology with structural biology and chemistry, this project aims to understand how the immune system detects molecules produced by diverse microorganisms.

该项目旨在评估能够刺激哺乳动物和两栖动物中维生素B反应性T细胞的分子的范围，以及这些分子在不同微生物中的保守或变异程度。T细胞是识别外来分子的免疫细胞，包括多肽、脂类和维生素B代谢物，与特定的抗原呈递分子结合。在哺乳动物中，粘膜相关不变T细胞识别以维生素B为基础的分子，目前仍知之甚少。这个项目将免疫学与结构生物学和化学相结合，旨在了解免疫系统如何检测不同微生物产生的分子。