Early evolution of the endomesoderm gene regulatory network

内中胚层基因调控网络的早期进化

• 批准号: FT160100068
• 负责人: A/Prof Maja Adamska
• 金额: $ 56.37万
• 依托单位: The Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: ARC Future Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/FT160100068
• 关键词: Early; evolution; endomesoderm; gene; regulatory

This project aims to unravel the endomesoderm gene network’s evolutionary history by identifying its conserved components’ target genes in the calcareous sponge Sycon. Little is known about the evolutionary origin of the developmental gene regulatory networks active in the development of all Eumetazoans (animals with nerves and digestive systems). Sponges are key models to study the transition from protists to eumetazoans, and gene expression data supports homology between sponge and eumetazoan tissues and body plans. This project could illuminate the evolutionary history of the animal body plan.

该项目旨在通过识别石灰质海绵Sycon中保守成分的靶基因来解开内中胚层基因网络的进化历史。关于所有真后生动物（具有神经和消化系统的动物）发育中活跃的发育基因调控网络的进化起源知之甚少。海绵是研究原生动物向真后生动物转变的关键模型，基因表达数据支持海绵和真后生动物组织和身体平面之间的同源性。这个项目可以阐明动物身体计划的进化历史。