权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

NURSING INTERVENTIONS IN POST-OPERATIVE RECOVERY

术后恢复中的护理干预

基本信息

批准号：
3419850
负责人：
LYNNE A FARR
金额：
--
依托单位：
UNIVERSITY OF NEBRASKA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1984
资助国家：
美国
起止时间：
1984-08-01 至 1986-07-31
项目状态：
已结题

项目摘要

The proposed research is based on the investigators' prior studies which found that surgical patients undergo disruption of their biological (circadian) rhythms following surgery and hospitalization. The more disrupted patients appeared to recover their rhythmicity at a slower rate than those with less disruption. Using an animal model, the rate of recovery following surgery was studied in relation to the degree of disruption, as well as to the rate at which rhythmicity was restored. The purposes of this study are: (1) To develop a pre-surgical protocol, using an animal model, which will prevent or minimize circadian disruption following surgery; (2) To test the effects of this pre-surgical protocol on a nonhuman animal model; (3) To test the use of the pre-surgical protocol on healthy human subjects; (4) To test the pre-surgical protocol in a human surgical population and to measure its effects on resulting circadian disruption. In the first series of experiments, various schedules of meal timing, exercise, rest/activity, and caffeine ingestion will be tested. A combination of the schedules will be developed which optimally alters the circadian rhythmicity in the normal individual in a pattern which will pre-adjust the individual before surgery in a manner similar to that developed for transmeridian flight by Ehret, Groh, Meinert (1980). In a series of parallel experiments, compliance with the self-measurement of biological rhythms (autorhythmometry) and compliance with the pre-surgical protocol will be tested. Finally, the pre-surgical protocol will be tested on a group of surgical patients to determine its effectiveness in preventing circadian disruption following surgery and in the recovery and restoration of rhythmic synchrony. Implementation of this protocol is expected to improve patient well-being and speed recovery.

拟议的研究是基于研究人员先前的研究，发现手术患者的生物学功能受到破坏，手术和住院后的（昼夜）节律。越中断的患者似乎以较慢的速度恢复他们的节律性而不是那些干扰较少的人。使用动物模型，研究了手术后的恢复情况，中断，以及恢复节律的速度。的本研究的目的是：（1）制定术前方案，使用一种动物模型，可以防止或最小化昼夜节律紊乱（2）测试该术前方案对以下患者的影响：非人类动物模型;（3）测试术前方案的使用在健康的人类受试者中;（4）在人类中测试手术前方案手术人群，并测量其对结果昼夜节律的影响破坏在第一系列的实验中，将测试时间、运动、休息/活动和咖啡因摄入。一将制定一系列的时间表，以最佳方式改变正常个体的昼夜节律，在手术前以类似的方式对个人进行预调整 Ehret，Groh，Meinert（1980）为跨子午线飞行而开发的。中系列平行实验，符合自我测量生物节律（自动节律）和术前顺应性将测试协议。最后，将测试术前方案对一组手术患者进行研究，以确定其在防止手术后和恢复期间的昼夜节律紊乱，恢复节奏同步。该协议的实施是有望改善患者的健康状况并加速康复。