NEUROPSYCHOLOGICAL ASPECTS OF STAGE II/III HIV INFECTION

II/III 期 HIV 感染的神经心理学方面

• 批准号: 3410381
• 负责人: Hugh Hunter Handsfield
• 金额: $ 26.8万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3410381
• 关键词: HIV infections; T lymphocyte; blood tests; cerebrospinal fluid; clinical chemistry; electroencephalography; enzyme linked immunosorbent assay; homosexuals; human immunodeficiency virus 1; human subject; immunologic techniques; longitudinal human study; magnetic resonance imaging; male; microorganism culture; neurologic manifestations; neuropsychological tests; neuropsychology; psychometrics; serology /serodiagnosis; tissue /cell culture; virus cytopathogenic effect; virus infection mechanism

The neurotropic properties of human immunodeficiency virus (HIV) are well established, as is the ability of HIV to cause primary neurological and psychological abnormalities in persons with overt acquired immunodeficiency syndrome (AIDS). There is little information, however, on the prevalence, clinical manifestations, natural course, and potential public health impact of neuropsychological aberrations in less severe forms of HIV infection. We will address these issues by conducting case control and prospective cohort studies in three groups of homosexually active men: 80 with persistent generalized lymphadenopathy (CDC group III HIV infection), many of whom have been studied in detail by us for up to four years; 80 asymptomatic HIV- seropositive men (CDC group II); and 80 HIV-seronegative men. Each subject will undergo serial detailed neurologic examinations, standardized neuropsychological (psychometric) testing, culture of peripheral blood lymphocytes for HIV, and monitoring of T lymphocyte subsets. The neuropsychological tests will include measurements of intelligence, attention, concentration, long- and short-term memory, cognitive flexibility, information processing, motor speed, visual discrimination, and other characteristics. Sixty of the HIV-infected subjects (30 each with group II and group III HIV infection) will undergo annual lumbar punctures with cerebrospinal fluid culture for HIV and determination of intrathical production of antibody to HIV. A subset of 40 subjects with stage II and 40 with stage III HIV infection (all of whom will undergo the CSF studies) will have serial magnetic resonance brain scans. The natural history of the neuropsychological manifestations of HIV infection will be determined by longitudinal followup for up to five years.

人类免疫缺陷病毒的神经营养特性 (艾滋病毒)是公认的，艾滋病毒引起 人的原发神经和心理异常 患有明显的获得性免疫缺陷综合征(艾滋病)。的确有 然而，很少有关于患病率、临床情况的信息。 表现形式、自然过程和潜在的公共卫生影响 不太严重的HIV患者的神经心理异常 感染。我们将通过实施病例控制来解决这些问题 和三组同性恋者的前瞻性队列研究 活动期男性：80例持续性全身性淋巴结病 (疾控中心第三组艾滋病毒感染)，其中许多已在 我们在长达四年的时间里提供了详细的信息；80个没有症状的艾滋病毒- 血清阳性男性(疾控中心II组)和80名HIV血清阴性男性。 每个受试者都将接受一系列详细的神经学检查， 标准化神经心理(心理测量)测试，培养 HIV的外周血淋巴细胞和T细胞的监测 淋巴细胞亚群。神经心理测试将包括 测量智力、注意力、专注力、长期和 短期记忆，认知灵活性，信息处理， 运动速度快、视觉辨别能力强等特点。 60名艾滋病毒感染者(第二组和第二组各30人 第三组HIV感染)将每年接受腰椎穿刺术 人类免疫缺陷病毒脑脊液培养及检测 在子宫内产生HIV抗体。40名受试者的子集 II期和40例HIV感染III期(所有人都会 进行脑脊液研究)将进行序列磁共振 脑部扫描。神经心理学的自然历史 艾滋病毒感染的表现将由纵向 随访时间长达五年。

项目成果

Unintegrated circular HIV-1 DNA in the peripheral mononuclear cells of HIV-1-infected subjects: association with high levels of plasma HIV-1 RNA, rapid decline in CD4 count, and clinical progression to AIDS.

HIV-1 感染者外周单核细胞中未整合的环状 HIV-1 DNA：与血浆 HIV-1 RNA 水平高、CD4 计数快速下降以及 AIDS 临床进展相关。

• DOI: 10.1097/00042560-199804010-00003
• 发表时间: 1998
• 期刊: Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
• 作者: Panther,LA;Coombs,RW;Zeh,JE;Collier,AC;Corey,L
• 通讯作者: Corey,L

Central nervous system manifestations in human immunodeficiency virus infection without AIDS.

无艾滋病的人类免疫缺陷病毒感染的中枢神经系统表现。

• 发表时间: 1992
• 期刊: Journal of acquired immune deficiency syndromes
• 作者: Collier,AC;Marra,C;Coombs,RW;Claypoole,K;Cohen,W;LongstrethJr,WT;Townes,BD;Maravilla,KR;Critchlow,C;Murphy,VL
• 通讯作者: Murphy,VL

Prospective cerebral MR study of HIV seropositive and seronegative men: correlation of MR findings with neurologic, neuropsychologic, and cerebrospinal fluid analysis.

HIV 血清阳性和血清阴性男性的前瞻性脑 MR 研究：MR 结果与神经学、神经心理学和脑脊液分析的相关性。

• 发表时间: 1992
• 期刊: AJNR. American journal of neuroradiology
• 作者: Cohen,WA;Maravilla,KR;Gerlach,R;Claypoole,K;Collier,AC;Marra,C;Maxwell,C;Coombs,RW;LongstrethJr,WT;Townes,BD
• 通讯作者: Townes,BD

Unintegrated HIV-1 circular 2-LTR proviral DNA as a marker of recently infected cells: relative effect of recombinant CD4, zidovudine, and saquinavir in vitro.

未整合的 HIV-1 环状 2-LTR 前病毒 DNA 作为最近感染细胞的标记：重组 CD4、齐多夫定和沙奎那韦的体外相对效应。

• DOI: 10.1002/(sici)1096-9071(199906)58:2
• 发表时间: 1999
• 期刊: Journal of medical virology
• 影响因子: 12.7
• 作者: Panther,LA;Coombs,RW;Aung,SA;delaRosa,C;Gretch,D;Corey,L
• 通讯作者: Corey,L

INTERMITTENT SHEDDING OF HUMAN-IMMUNODEFICIENCY-VIRUS IN SEMEN - IMPLICATIONS FOR SEXUAL TRANSMISSION

• DOI: 10.1016/s0022-5347(01)66969-6
• 发表时间: 1995-09-01
• 期刊: JOURNAL OF UROLOGY
• 影响因子: 6.6
• 作者: KRIEGER, JN;COOMBS, RW;COREY, L
• 通讯作者: COREY, L