课题基金 / 基金详情

HYPOMYELINATION IN TRANSGENICS--MODEL FOR PML

HYPOMYELINATION IN TRANSGENICS--MODEL FOR PML
转基因中的低髓鞘形成——PML 模型
批准号:
2265389
负责人:
GEORGE A SCANGOS
金额:
$10.11万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-09-07 至 1988-08-31

项目摘要

项目成果

GEORGE A SCANGOS的其他基金

相似基金

相关文献

中文摘要
翻译
JC病毒(JCV)是一种在人类中广泛传播的人乳头状病毒
英文摘要
JC virus (JCV) is human papovavirus that is widespread in human populations. Infections usually occur in childhood and normally are subclinical. However, in a small number of patients whose immunity has been compromised by disease, genetic disorders, or therapy, JC has been implicated as a causative agent in the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML). Although PML is rare, the incidence has risen somewhat recently because of the large pool of immuno-compromised AIDS patients. JC viral particles can be isolated from brain lesions of patients with PML, in which there are abnormal oligodendrocytes and astrocytes. Demyelination is caused by destruction of oligodendrocytes, the myelin-producing cells of the central nervous system. Transgenic mice containing the early region of JC virus have been generated, and two lines of mice have a dysmyelination in the central nervous system. These mice therefore provide an animal model for this human demyelinating disease. It is anticipated that analyses of the transgenic mice will lead to insight into the biochemical processes involved in PML. Initial analyses of these mice demonstrated expression in oligodendrocytes. Additional mice harboring naturally occurring JC variants will be generated and mice will be analyzed to determine the tissue- and development-specific patterns of expression of the JCV early regions. Analyses of the myelin specific proteins myelin basic protein (MBP), proteo-lipid protein (PLP), and myelin-associated glycoprotein (MAG) will be performed. For MBP and PLP, expression will be determined at several stages of development at both the RNA and protein levels. For MAG, where a nucleic acid probe is not available, expression will be limited to the protein level. Attempts will be made to identify and isolate protein factors that bind to, and regulate expression of, the JC early region. It is anticipated that some of these same factors also will regulate expression of the myelin- specific proteins.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DETECTION AND ANALYSIS OF ONC GENES IN DEFINED MEDIA
  • 批准号:
    3180717
  • 项目类别:
  • 资助金额:
    $10.1万
  • 财政年份:
    1985
  • 负责人:
    GEORGE A SCANGOS
  • 依托单位:
DETECTION AND ANALYSIS OF ONC GENES IN DEFINED MEDIA
  • 批准号:
    3180716
  • 项目类别:
  • 资助金额:
    $9.87万
  • 财政年份:
    1985
  • 负责人:
    GEORGE A SCANGOS
  • 依托单位:
GENE TRANSFER AND GENE EXPRESSION IN MAMMALIAN CELLS
  • 批准号:
    3276350
  • 项目类别:
  • 资助金额:
    $9.62万
  • 财政年份:
    1983
  • 负责人:
    GEORGE A SCANGOS
  • 依托单位:
国内基金
海外基金
Ascl1介导Wnt/beta-catenin通路在TLE海马硬化中反应性Astrocytes异常增生的作用及调控机制
  • 批准号:
    31760279
  • 项目类别:
    地区科学基金项目
  • 资助金额:
    35.0万元
  • 批准年份:
    2017
  • 负责人:
    丁银秀
  • 依托单位: