EMISSION COMPUTED TOMOGRAPHY OF LOCAL CEREBRAL FUNCTION

局部脑功能的发射计算机断层扫描

• 批准号: 3409912
• 负责人: DAVID E KUHL
• 金额: $ 40.85万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3409912
• 关键词: blood volume; brain edema; brain injury; brain mapping; brain neoplasms; clinical biomedical equipment; computed axial tomography; glucose metabolism; human subject; neoplasm /cancer radionuclide diagnosis; radionuclide imaging /scanning; radiotracer; stroke

We propose to develop relatively atraumatic study methods that may be applied to patients for determining accurately and precisely measurements of local cerebral function in terms of absolute values of circulation and metabolism. By means of emission computed tomography of appropriately chosen radioactive indicators given intravenously, tracer distributions will be quantified with three-dimensional localization. Once validated, these methods will be applied to improve understanding of basic human cerebral physiology and will be evaluated for their usefulness in enhancing the diagnosis and management of patients with cerebrovascular disease, seizure disorders, and metabolic encephalopathies.

我们建议开发相对无创伤的研究方法， 应用于患者，以准确和精确地确定测量值 局部脑功能的绝对值循环和 新陈代谢. 通过适当的发射计算机断层扫描 静脉注射选定的放射性指示剂，示踪剂分布 将通过三维定位进行量化。 一旦验证， 这些方法将被应用于改善对基本人类的理解。 大脑生理学，并将评估其在增强 脑血管病患者的诊断和管理， 癫痫和代谢性脑病。