Positron Tomograph for Preclinical Research

用于临床前研究的正电子断层扫描仪

• 批准号: 6440844
• 负责人: DAVID E KUHL
• 金额: $ 50万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6440844
• 关键词: biomedical equipment purchase; positron emission tomography

This application for shared instrumentation requests partial support for the purchase of a replacement position tomograph for preclinical research to be located in The University of Michigan Cyclotron/PET Center. A number of NIH-funded investigators have research needs for determining the biodistribution of a positron-labeled radiotracers in experimental animals. At present, the Cyclotron/PET facility makes use of a dedicated, 18-year old animal PET that has now become unserviceable. This grant requests funds to replace the existing tomograph with a modern, functional scanner capable of imaging primate brain as well as well as other small animals with high anatomic resolution and good sensitivity. The proposed replacement tomograph will permit not only the continuation of ongoing NIH-supported research, but will facilitate the development of new projects and users in emerging areas of radiotracer biomedical imaging. A major prior use of preclinical PET imaging was in the development and characterization of novel radiotracers. After initial biodistribution studies in small animal models (usually rodents), in vivo primate imaging studies are performed to verify the suitability of the radiotracer and the chosen analytical approach before extending the new tracer to human clinical studies. This will continue to be an essential research function served by the replacement tomograph. A second major area of tomograph utilization involves targeted research in animal models of neurological, cardiac and oncological disorders. The ability to determine radiotracer distributions non-invasively with PET permits the design of longitudinal experimental protocols. This considerably reduces the numbers of animals needed in comparison to designs employing invasive invasive measures of tracer distribution, and is particularly essential to experiments where significant inter-individual variability is expected (e.g.: some experimental lesion models, gene transfection studies, etc.) Or where there is considerable investment in the animals (e.g. primate studies).

此共享仪器应用程序要求部分支持购买位于密歇根大学回旋加速器/正电子发射计算机断层扫描中心的临床前研究的替代位置断层扫描仪。许多由美国国立卫生研究院资助的研究人员需要确定正电子标记的放射性示踪剂在实验动物中的生物分布。目前，回旋加速器/PET设施使用的是一种专用的、已有18年历史的动物PET，现在已经无法使用。这笔赠款要求提供资金，用现代的功能扫描仪取代现有的断层扫描仪，该扫描仪能够成像灵长类动物的大脑以及其他具有高解剖分辨率和良好灵敏度的小动物。拟议的替代断层扫描仪不仅将允许继续进行由美国国立卫生研究院支持的研究，而且将促进放射性示踪生物医学成像新兴领域的新项目和用户的开发。临床前PET成像的一个主要用途是开发和表征新的放射性示踪剂。在小动物模型(通常是啮齿动物)的初步生物分布研究之后，在将新的示踪剂扩展到人类临床研究之前，进行体内灵长类成像研究，以验证放射性示踪剂和所选择的分析方法的适用性。这将继续是替代断层摄影术所提供的一项基本研究功能。断层摄影术应用的第二个主要领域涉及对神经、心脏和肿瘤疾病的动物模型进行有针对性的研究。用正电子发射计算机断层扫描非侵入性确定放射性示踪剂分布的能力允许设计纵向实验方案。与使用示踪剂分布的侵入性措施的设计相比，这大大减少了所需的动物数量，对于预期个体间显著差异的实验尤其重要(例如：一些实验性病变模型、基因转染研究等)。或者在动物方面有相当大的投资(例如灵长类研究)。