EMISSION COMPUTED TOMOGRAPHY OF LOCAL CEREBRAL FUNCTION

局部脑功能的发射计算机断层扫描

• 批准号: 6297000
• 负责人: DAVID E KUHL
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6297000
• 关键词: Alzheimer's disease; Parkinson's disease; biomarker; brain metabolism; cholinergic receptors; clinical research; glucose metabolism; human subject; longitudinal human study; muscarinic receptor; positron emission tomography

The goal of this project is to identify and examine longitudinally, with positron emission tomography, the earliest alterations in cerebral physiology associated with the onsets of Alzheimer's disease and of parkinsonian dementia. PET determined measures of cerebral glucose metabolism, blood flow, muscarinic cholinergic receptor densities, and presynaptic cholinergic markers will be determined in cross-sectional and longitudinal studies of controls and patients with dementing diseases.

该项目的目标是用正电子发射断层扫描纵向识别和检查与阿尔茨海默病和帕金森痴呆症发病相关的脑生理学的最早改变。 PET测定的脑葡萄糖代谢、血流量、毒蕈碱胆碱能受体密度和突触前胆碱能标记物的测量将在对照组和痴呆疾病患者的横断面和纵向研究中确定。