MULTICHANNEL IMPLANTABLE SYSTEM FOR NEURAL CONTROL

用于神经控制的多通道植入系统

• 批准号: 2267696
• 负责人: Paul Hunter Peckham
• 金额: $ 18.15万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-05-01 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2267696
• 关键词: bioengineering /biomedical engineering; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biosensor device; dogs; implant; muscle function; nervous system prosthesis; neuromuscular stimulator; rehabilitation; spinal cord injury; telemedicine; titanium

The long term objective of this project is to restore control of motor and sensory function in individuals with central nervous system paralysis through the use of neural prostheses employing electrical stimulation. Specifically, neural prosthetic systems for control of hand-arm function provide the individual paralyzed with high cervical level spinal cord injury with enhanced manipulation skills, thus improving his/her independence in daily activities. The specific aim of this project is to develop an integrated multichannel implantable system which, when introduced clinically, will provide the user with simplified use of the system and enhanced functional capabilities. This will be provided through the use of implanted sensors for control and feedback, telemetry to transmit these signals transcutaneously, and the capacity for activating more muscles. The focus of this project is on the development of the advanced implantable hardware system and its evaluation. The system to be developed will integrate a multichannel telemetry system and a multichannel stimulator with an implanted joint angle sensor. The single telemetry/stimulation device will be designed and fabricated using low power microelectronic circuitry for activation of up to 12 muscles and telemetry of up to three joint angle sensors and two myoelectric channels. A single radiofrequency signal will be used to power the system and transmit stimulus and control commands. The telemetry/stimulator device will be hermetically sealed in titanium and conformally coated with epoxy and elastomer which are suitable for chronic implantation. Joint angle transducers employing Hall effect sensors, recording and stimulation electrodes, and lead interconnections also will be fabricated. The system will be evaluated in in vitro and in vivo testing to insure proper operation over time. Accelerated bench tests will stress the electronics. In vitro tests will provide observable performance in a continuously monitored environment. In vivo testing in a dog model will demonstrate the long term stability of performance of the implanted system over time. At the completion of these studies, we expect to have developed and completed the evaluation of an advanced system for neural prosthetic applications which is suitable for human application.

该项目的长期目标是恢复对电机的控制 中枢神经系统麻痹患者的感觉功能 通过使用电刺激的神经假体。 具体来说，用于控制手臂功能的神经假体系统 为高位颈段脊髓瘫痪的患者提供 提高操作技能，从而提高他/她的 日常活动中的独立性。 该项目的具体目标是 开发一种集成的多通道植入式系统，当 在临床上引入，将为用户提供简化的 系统和增强的功能。 这将通过以下方式提供： 使用植入的传感器进行控制和反馈，遥测， 传输这些信号transmitted transmitted，and the capacity容量for activating激活 更多肌肉 该项目的重点是开发先进的 植入式硬件系统及其评价。 待开发的系统 将集成多通道遥测系统和多通道 植入关节角度传感器的刺激器。 单 遥测/刺激装置将使用低 动力微电子电路激活多达12个肌肉和 遥测多达三个关节角度传感器和两个肌电通道。 单个射频信号将用于为系统供电， 发送刺激和控制命令。 遥测/刺激器装置 将密封在钛和共形涂环氧树脂 和弹性体。 关节角度 采用霍尔效应传感器、记录和激励的换能器 还将制造电极和引线互连。 系统 将在体外和体内试验中进行评估，以确保适当的 随着时间的推移。 加速台架测试将对电子设备施加压力。 体外试验将提供可观察到的性能， 监控环境。在狗模型中的体内测试将证明 植入系统性能随时间的长期稳定性。 在 在完成这些研究后，我们预计已制定和完成 神经修复应用先进系统的评价 适合人体应用。