PAPILLOMAVIRUS AND ORAL CANCER--A CASE-CONTROL STUDY

乳头状病毒和口腔癌——病例对照研究

• 批准号: 2097968
• 负责人: KAREN ADLER STORTHZ
• 金额: $ 3.72万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-05-01 至 1995-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2097968
• 关键词: antibody formation; antiviral antibody; automated medical record system; cancer risk; data collection; enzyme linked immunosorbent assay; human papillomavirus; human subject; mouth neoplasms; oncogenic virus; oral mucosa; questionnaires; synthetic peptide; viral carcinogenesis; virus diseases; virus related neoplasm /cancer

Human papillomavirus (HPV) is prevalent in the oral mucosa and may be involved in the etiology of oral squamous cell carcinoma. No study to date has evaluated HPV as a risk factor for oral cancer. The proposed research is a case-control of 65 patients registered at the University of Texas M.D. Anderson Cancer Center with previously untreated, histologically confirmed oral squamous cell carcinoma and 74 age-, sex- and race-matched controls. The cases and controls have been accrued, and medical history questionnaire data have been collected and automated. Collection of laboratory data concerning the prevalence of HPV and mutagen-induced chromosome breakage was recently completed. The measurement of the antibody response to HPV will be accomplished using HPV-derived synthetic peptides as antigens in an enzyme-linked immunoassay. The serologic response data and HPV prevalence and typing data will be evaluated as risk factors for oral cancer in univariate analysis. Data from self-administered risk factor questionnaires and mutagen-induced chromosome sensitivity data will be integrated with the HPV data. The results of the proposed study will provide a basis for larger prospective studies to evaluate HPV infection as a possible marker for tumor development.

人乳头瘤病毒(HPV)在口腔粘膜中普遍存在，可能是 参与口腔鳞癌的病因学研究。没有研究要做 Date已经评估HPV是口腔癌的危险因素。建议数 这项研究是对在加州大学注册的65名患者进行的病例对照研究 德克萨斯州M.D.安德森癌症中心，之前未接受治疗， 组织学证实的口腔鳞状细胞癌和74例年龄、性别- 和种族匹配的对照。案件和控制措施已经累积，并且 病史问卷数据已被收集并自动化。 收集有关人乳头瘤病毒和人乳头瘤病毒流行的实验室数据 诱变剂诱导的染色体断裂最近完成了。这个 对人乳头瘤病毒抗体反应的测量将使用 人乳头瘤病毒衍生的合成肽作为抗原在一种酶连接的 免疫分析。血清学反应数据与人乳头瘤病毒感染及分型 数据将作为口腔癌的危险因素进行单变量评估 分析。数据来自自我管理的风险因素问卷和 诱变剂诱发的染色体敏感性数据将与 人乳头瘤病毒数据。拟议研究的结果将为 评估HPV感染作为可能标志物的更大规模前瞻性研究 用于肿瘤的发展。