PAPILLOMAVIRUS AND ORAL CANCER--A CASE-CONTROL STUDY

人乳头瘤病毒(HPV)在口腔粘膜中普遍存在，可能是 参与口腔鳞癌的病因学研究。没有研究要做 Date已经评估HPV是口腔癌的危险因素。建议数 这项研究是对在加州大学注册的65名患者进行的病例对照研究 德克萨斯州M.D.安德森癌症中心，之前未接受治疗， 组织学证实的口腔鳞状细胞癌和74例年龄、性别- 和种族匹配的对照。案件和控制措施已经累积，并且 病史问卷数据已被收集并自动化。 收集有关人乳头瘤病毒和人乳头瘤病毒流行的实验室数据 诱变剂诱导的染色体断裂最近完成了。这个 对人乳头瘤病毒抗体反应的测量将使用 人乳头瘤病毒衍生的合成肽作为抗原在一种酶连接的 免疫分析。血清学反应数据与人乳头瘤病毒感染及分型 数据将作为口腔癌的危险因素进行单变量评估 分析。数据来自自我管理的风险因素问卷和 诱变剂诱发的染色体敏感性数据将与 人乳头瘤病毒数据。拟议研究的结果将为 评估HPV感染作为可能标志物的更大规模前瞻性研究 用于肿瘤的发展。

Human papillomavirus (HPV) is prevalent in the oral mucosa and may be involved in the etiology of oral squamous cell carcinoma. No study to date has evaluated HPV as a risk factor for oral cancer. The proposed research is a case-control of 65 patients registered at the University of Texas M.D. Anderson Cancer Center with previously untreated, histologically confirmed oral squamous cell carcinoma and 74 age-, sex- and race-matched controls. The cases and controls have been accrued, and medical history questionnaire data have been collected and automated. Collection of laboratory data concerning the prevalence of HPV and mutagen-induced chromosome breakage was recently completed. The measurement of the antibody response to HPV will be accomplished using HPV-derived synthetic peptides as antigens in an enzyme-linked immunoassay. The serologic response data and HPV prevalence and typing data will be evaluated as risk factors for oral cancer in univariate analysis. Data from self-administered risk factor questionnaires and mutagen-induced chromosome sensitivity data will be integrated with the HPV data. The results of the proposed study will provide a basis for larger prospective studies to evaluate HPV infection as a possible marker for tumor development.