TIME-DEPENDENT EFFECT OF ALCOHOL ON SPONTANEOUS ABORTION
TIME-DEPENDENT EFFECT OF ALCOHOL ON SPONTANEOUS ABORTION
批准号:
3422194
负责人:
GAYLE C WINDHAM
金额:
$1.88万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1992
资助国家:
美国
项目状态:
已结题
起止时间:
1992-08-01 至 1994-07-31
中文摘要
本建议的目的是评估适度的效果
英文摘要
The purpose of this proposal is to assess the effect of moderate
alcohol consumption at different stages of pregnancy on the risk
of spontaneous abortion (SAB), using a unique data base. Heavy
alcohol consumption during pregnancy is known to cause adverse
reproductive outcomes, but studies on moderate consumption are
less consistent. This is an important public health issue because
"social" drinking of alcoholic beverages is very common in the
United States, so if it represents a risk factor for SAB, many
pregnancies are potentially affected. On the order of 10-15% of
pregnant women experience a clinical spontaneous abortion and
another 20% of conceptuses may be lost before pregnancy is
medically recognized. The critical period of exposure to alcohol
is unknown. Although many women follow advice to decrease alcohol
consumption once pregnancy is recognized, their consumpiion before
or very early in pregnancy may be important, warranting further
public health intervention. This study will be one of the largest
prospective studies of SAB to examine alcohol exposure. Data were
collected in a multi-center study of pregnancy outcome recently
conducted by the California Department of Health Services and the
Kaiser Permanente Medical Care Program. Pregnant women (5300)
from three Kaiser facilities were interviewed during their first
trimester about a variety of factors, including usual alcohol
consumption before pregnancy, whether and when it changed during
the first trimester, and maximum consumption. The information on
change in usual alcohol consumption provides data on exposure
before and during early pregnancy, as well as a more accurate
assessment of weekly exposure than is obtained by asking women how
much they "usually" drank during pregnancy. Another feature of
the data is the information on the greatest amount of alcohol
consumed on one occasion and when in pregnancy it occurred, which
can be used as a measure of binge drinking. The analysis will use
proportional hazards models to calculate the risk of SAB by
gestational age, with alcohol consumption during a specified time
period as the primary explanatory variable, adjusted for other
covariates. The models will be expanded to examine alcohol as a
time-dependent variable as well. Mechanisms of action will be
further explored by comparing results between sub-sets of SABs
which may have different etiologies. Funds are being sought to
provide a research analyst, biostatistical consultation and other
support to conduct these complex analyses.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1097/00001648-199709000-00007
发表时间:
1997
期刊:
Epidemiology (Cambridge, Mass.)
影响因子:
--
作者:
[Windham,GC, VonBehren,J, Fenster,L, Schaefer,C, Swan,SH]
通讯作者:
Swan,SH
California Monitoring of Early Childhood Autism (CA-MECA)
-
批准号:7883253
-
项目类别:
-
资助金额:$35.35万
-
财政年份:2007
-
负责人:GAYLE C WINDHAM
-
依托单位:
California Monitoring of Early Childhood Autism (CA-MECA)
-
批准号:7409919
-
项目类别:
-
资助金额:$35.0万
-
财政年份:2007
-
负责人:GAYLE C WINDHAM
-
依托单位:
California Monitoring of Early Childhood Autism (CA-MECA)
-
批准号:7487559
-
项目类别:
-
资助金额:$35.0万
-
财政年份:2007
-
负责人:GAYLE C WINDHAM
-
依托单位:
California Monitoring of Early Childhood Autism (CA-MECA)
-
批准号:7658340
-
项目类别:
-
资助金额:$34.96万
-
财政年份:2007
-
负责人:GAYLE C WINDHAM
-
依托单位:
PRENATAL AND CHILDHOOD EXPOSURES AND AGE AT MENARCHE
-
批准号:6363419
-
项目类别:
-
资助金额:$3.32万
-
财政年份:2000
-
负责人:GAYLE C WINDHAM
-
依托单位:
PRENATAL AND CHILDHOOD EXPOSURES AND AGE AT MENARCHE
-
批准号:6045048
-
项目类别:
-
资助金额:$4.87万
-
财政年份:2000
-
负责人:GAYLE C WINDHAM
-
依托单位:
ORGANOCHLORINE COMPOUNDS AND MENSTRUAL CYCLE FUNCTION
-
批准号:6055959
-
项目类别:
-
资助金额:$10.97万
-
财政年份:1996
-
负责人:GAYLE C WINDHAM
-
依托单位:
ORGANOCHLORINE COMPOUNDS AND MENSTRUAL CYCLE FUNCTION
-
批准号:2770792
-
项目类别:
-
资助金额:$11.47万
-
财政年份:1996
-
负责人:GAYLE C WINDHAM
-
依托单位:
ORGANOCHLORINE COMPOUNDS AND MENSTRUAL CYCLE FUNCTION
-
批准号:2518710
-
项目类别:
-
资助金额:$11.55万
-
财政年份:1996
-
负责人:GAYLE C WINDHAM
-
依托单位:
ORGANOCHLORINE COMPOUNDS AND MENSTRUAL CYCLE FUNCTION
-
批准号:2157695
-
项目类别:
-
资助金额:$11.91万
-
财政年份:1996
-
负责人:GAYLE C WINDHAM
-
依托单位:
TIME-DEPENDENT EFFECT OF ALCOHOL ON SPONTANEOUS ABORTION
-
批准号:2045593
-
项目类别:
-
资助金额:$3.46万
-
财政年份:1992
-
负责人:GAYLE C WINDHAM
-
依托单位: