TIME-DEPENDENT EFFECT OF ALCOHOL ON SPONTANEOUS ABORTION

酒精对自然流产的时间依赖性影响

• 批准号: 3422194
• 负责人: GAYLE C WINDHAM
• 金额: $ 1.88万
• 依托单位: PUBLIC HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-01 至 1994-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3422194
• 关键词: alcoholic beverage consumption; disease /disorder proneness /risk; epidemiology; human data; pregnancy; spontaneous abortion

The purpose of this proposal is to assess the effect of moderate alcohol consumption at different stages of pregnancy on the risk of spontaneous abortion (SAB), using a unique data base. Heavy alcohol consumption during pregnancy is known to cause adverse reproductive outcomes, but studies on moderate consumption are less consistent. This is an important public health issue because "social" drinking of alcoholic beverages is very common in the United States, so if it represents a risk factor for SAB, many pregnancies are potentially affected. On the order of 10-15% of pregnant women experience a clinical spontaneous abortion and another 20% of conceptuses may be lost before pregnancy is medically recognized. The critical period of exposure to alcohol is unknown. Although many women follow advice to decrease alcohol consumption once pregnancy is recognized, their consumpiion before or very early in pregnancy may be important, warranting further public health intervention. This study will be one of the largest prospective studies of SAB to examine alcohol exposure. Data were collected in a multi-center study of pregnancy outcome recently conducted by the California Department of Health Services and the Kaiser Permanente Medical Care Program. Pregnant women (5300) from three Kaiser facilities were interviewed during their first trimester about a variety of factors, including usual alcohol consumption before pregnancy, whether and when it changed during the first trimester, and maximum consumption. The information on change in usual alcohol consumption provides data on exposure before and during early pregnancy, as well as a more accurate assessment of weekly exposure than is obtained by asking women how much they "usually" drank during pregnancy. Another feature of the data is the information on the greatest amount of alcohol consumed on one occasion and when in pregnancy it occurred, which can be used as a measure of binge drinking. The analysis will use proportional hazards models to calculate the risk of SAB by gestational age, with alcohol consumption during a specified time period as the primary explanatory variable, adjusted for other covariates. The models will be expanded to examine alcohol as a time-dependent variable as well. Mechanisms of action will be further explored by comparing results between sub-sets of SABs which may have different etiologies. Funds are being sought to provide a research analyst, biostatistical consultation and other support to conduct these complex analyses.

本建议的目的是评估适度的影响， 饮酒对怀孕不同阶段的风险 使用独特的数据库进行自然流产（SAB）的研究。 重 怀孕期间饮酒会导致不良反应。 生殖结果，但对适度消费的研究是 不太一致。 这是一个重要的公共卫生问题，因为 "社交"饮酒在美国非常普遍， 美国，所以如果它代表了SAB的风险因素，许多 怀孕可能会受到影响。 约为10 - 15%， 孕妇经历临床自然流产， 另外20%的孕体可能在怀孕前丢失， 医学上承认。 接触酒精的关键时期 不明 尽管许多女性听从建议减少饮酒， 消费一旦怀孕是公认的，他们的消费之前， 或怀孕早期可能很重要， 公共卫生干预。 这项研究将是最大的 SAB的前瞻性研究，以检查酒精暴露。 数据 最近在一项多中心妊娠结局研究中收集到的 由加州卫生服务部和 Kaiser Permanente医疗护理计划。 孕妇（5300） 在他们的第一次采访中， 妊娠期的各种因素，包括通常的酒精 怀孕前是否以及何时发生变化， 第一个三个月，最大消费量。 上的信息 日常饮酒量的变化提供了暴露数据 怀孕前和怀孕早期，以及更准确的 每周暴露的评估，而不是通过询问女性如何获得 他们在怀孕期间“通常”喝多少。 的另一个特征 数据是关于最大酒精含量的信息 在怀孕期间食用， 可用作衡量酗酒的标准。 分析将使用 比例风险模型计算SAB的风险， 胎龄，在特定时间内饮酒 作为主要解释变量，调整其他 协变量 这些模型将被扩展到研究酒精作为一种 时间依赖变量也是如此。 作用机制将是 通过比较SAB子集之间的结果进一步探索 可能有不同的病因。 正在寻求资金， 提供研究分析，生物统计咨询和其他 支持进行这些复杂的分析。

项目成果

Moderate maternal alcohol consumption and risk of spontaneous abortion.

母亲适度饮酒和自然流产的风险。

• DOI: 10.1097/00001648-199709000-00007
• 发表时间: 1997
• 期刊: Epidemiology (Cambridge, Mass.)
• 作者: Windham,GC;VonBehren,J;Fenster,L;Schaefer,C;Swan,SH
• 通讯作者: Swan,SH