IRON DEFICIENCY ANEMIA AND INFANT BEHAVIOR

缺铁性贫血和婴儿行为

• 批准号: 3432572
• 负责人: BETSY LOZOFF
• 金额: $ 1.59万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-08-17 至 1993-08-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3432572
• 关键词: attention; auditory stimulus; behavior test; child behavior; child mental disorders; child psychology; cognition; diet therapy; dietary iron; dietary supplements; electrocardiography; electroencephalography; electromyography; electrooculography; evoked potentials; human subject; human therapy evaluation; infant human (0-1 year); memory; microcytic /hypochromic anemia; mother child interaction; neuropsychological tests; neuropsychology; nutrition related tag; play; preschool child (1-5); questionnaires; sleep; videotape /videodisc; visual stimulus

The proposed FIRCA grant extends and expands a five-year U.S.-Chile collaborative study of the behavioral effects of iron deficiency anemia in infancy. The FIRCA award relates to Study II of the ongoing project. Study II will determine if there is a period of differential vulnerability to behavioral effects of iron deficiency anemia by characterizing alterations in affect, attention, activity, and neurophysiologic maturation of anemic infants who are identified at 6, 12, or 18 mos of age (n = 100 at each age). A comparison group of nonanemic infants at each age will provide baseline data for developmental progressions in children who maintain better iron status. Study II also focuses on ways to improve the behavior and development of infants who do develop iron deficiency anemia. Previous studies have shown that altered behavior and lower developmental test scores do not improve with iron therapy in most anemic infants and that behavioral differences are still apparent at school entry. This study will determine if providing family-based intervention in addition to iron therapy can correct the altered behavior and if intervention is more effective in the first or in the second year of life. Anemic and nonanemic infants at each age will be randomly assigned to receive iron therapy alone or iron therapy plus a home-based program of support for the child's development. Behavior and development will be compared before and after six and twelve months of intervention. A FIRCA award will accomplish three new goals: 1) to train Chilean co-investigators in behavioral analyses, 2) to allow the neurophysiologic laboratory in Chile to use improved equipment and techniques for studying neurophysiologic maturation in iron deficiency anemia, and 3) to permit Chilean co-investigators to modify the early intervention program so that it reflects the most current, thinking in the field and yet is culturally sensitive to Chile. The FIRCA grant would thus foster the development of Chilean collaborators so that they may achieve leadership roles in new areas and would allow INTA, the collaborating institution in Chile, to expand its longstanding function as a resource for nutrition related investigations throughout Latin America.

拟议的FIRCA赠款延长和扩大了一个为期五年的美国-智利 缺铁性贫血对行为影响的合作研究 在婴儿期。FIRCA裁决涉及正在进行的项目的研究II。 研究二将确定是否有一个时期的差异， 易受缺铁性贫血的行为影响， 表征情感、注意力、活动和 在6岁时确定的贫血婴儿的神经生理学成熟， 12或18个月龄（每个年龄n = 100）。 的对照组 每个年龄段的非贫血婴儿将提供以下基线数据： 保持较好铁状态的儿童的发育进展。 第二项研究还侧重于如何改善儿童的行为和发展， 患缺铁性贫血的婴儿。 先前的研究 行为改变和发育测试分数降低并不意味着 铁剂治疗改善大多数贫血婴儿的行为 在入学方面，差异仍然很明显。 本研究将 确定除了铁之外， 治疗可以纠正改变的行为，如果干预更多 在生命的第一年或第二年有效。 贫血和 每个年龄段的非贫血婴儿将被随机分配接受铁 单独治疗或铁治疗加家庭支持计划， 孩子的发展。 行为和发展将被比较 分别在6个月和12个月的干预之前和之后。 FIRCA奖 将实现三个新的目标：1）培训智利合作研究人员， 行为分析，2）让智利的神经生理实验室 使用改进的设备和技术来研究神经生理学 成熟的缺铁性贫血，和3）允许智利 共同研究者修改早期干预计划， 反映了该领域最新的思想，但在文化上 对智利很敏感。 因此，FIRCA赠款将促进以下方面的发展 智利合作者，以便他们可以在新的 这将使智利的合作机构INTA能够 扩大其作为与营养有关的资源的长期职能 在整个拉丁美洲进行调查。