MEETING ON N-NITROSO COMPOUNDS MYCOTOXINS & TOBACCO

正亚硝基化合物霉菌毒素会议

• 批准号: 3434020
• 负责人: HELMUT BARTSCH
• 金额: $ 0.8万
• 依托单位: INTERNATIONAL AGENCY FOR RES ON CANCER
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-04-14 至 1990-04-13
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434020
• 关键词: cancer prevention; carcinogens; chemical carcinogenesis; disease /disorder proneness /risk; meeting /conference /symposium; mycotoxins; nitroso compounds; tobacco

An international, multi-disciplinary conference will be convened in Beijing, China, (July 2-7, 1989) on "N-Nitroso Compounds (NOC), mycotoxins and tobacco smoke: Relevance to Human Cancer". This lOth meeting of the series will discuss progress made in exposure assessment, health hazard and etiology of human cancers (respiratory tract, oesophagus, stomach, nasopharynx and liver), where these carcinogens are implicated. New results in the mechanisms of how carcinogenic nitroso compounds, certain mycotoxins and tobacco-derived carcinogens, act at a molecular, biochemical and biological level in animals and in human cells/tissues will be presented. Collaborative international studies and investigations on the etiology of cancers, both at high incidence in China and also linked to these agents, will be summarized. Current applications of chemical and biochemical dosimetry methods in human studies will be described for: 1) identification of carcinogenic hazards; 2) identification of high-risk groups/subjects based on the intensity of exposure and heterogeneity of adduct levels in tissues or body fluids; 3) more precise estimates of the internal and biologically effective doses of genotoxic chemicals in exposed human individuals and of efficacy of cancer protective agents in lowering them. Priorities and potentials for cancer prevention, in particular cessation of tobacco use, vaccination programs and dietary intervention/chemoprevention trials for the most prevalent cancers in China, will be discussed. A workshop for technology transfer on dosimetry methods and exchange of information with Chinese scientists will be held. The meeting will consist of equal parts of invited and preferred (new) papers, followed by a workshop. The proceedings will be published as an IARC Scientific Publication(*). *copies supplied of the Proceedings of the previous meeting.

将召集一次国际多学科会议 在中国北京，（1989年7月2日至7日）在“ N-硝基化合物（NOC）， 霉菌毒素和烟草烟雾：与人类癌症相关”。 该系列的LOTH会议将讨论曝光方面取得的进展 人类癌症的评估，健康危害和病因 （呼吸道，食道，胃，鼻咽和肝脏）， 这些致癌物涉及的地方。 新结果 致癌硝基化合物的机制，某些 霉菌毒素和烟草衍生的致癌物，作用于分子， 动物和人类的生化和生物学水平 细胞/组织将出现。 国际协作 对癌症病因的研究和研究都在很高 中国发病率，也与这些代理有关，将是 总结。 化学和生化剂量测定法的当前应用 在人类研究中将描述：1）识别 致癌危害； 2）识别高风险 基于暴露强度的组/受试者 组织或体液中加合物水平的异质性； 3）更多 内部和生物学有效剂量的精确估计 暴露于人类和功效的遗传毒性化学物质 降低癌症保护剂的癌症保护剂。 预防癌症的优先级和潜力，特别是 停止烟草使用，疫苗接种计划和饮食 干预/化学预防试验最普遍的癌症 在中国将讨论。 技术转移研讨会 关于剂量法和信息交换 科学家将被举行。 会议将由受邀和首选的同等部分组成 （新）论文，然后是研讨会。 程序将是 出版为IARC科学出版物（*）。 *上次会议的诉讼程序提供的副本。