1987 GORDON RESEARCH CONFERENCE ON ELASTIN

1987 年戈登弹性蛋白研究会议

• 批准号: 3435617
• 负责人: ROBERT P. MECHAM
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-01 至 1988-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435617
• 关键词: cardiovascular disorder; gene expression; molecular pathology; pulmonary fibrosis /granuloma; pulmonary hypertension; skin disorder; travel

This proposal seeks support for the fifth bi-annual Gordon Research Conference on Elastin. The conference will provide an important format for the exchange of new information and the development of new concepts concerning the structure of elastin and its precursor, its role as a biological elastomer, the analysis of the elastin gene and the control of its expression at the molecular, cell and tissue levels, elastin-associated macromolecules, enzymatic mechanisms of degradation of elastin and physiological inhibitors of elastolytic enzymes. Most importantly, the format for the 1987 meeting has been arranged to emphasize disease associated with perturbations in elastin content or structure. Lung disease will be a major focus with one session devoted to fibrotic and interstitial diseases and a second session dealing with pulmonary hypertension. in a session devoted to vascular disciplines with expertise on growth factors and inflammatory cell products since these molecules may play an important role in modulating the phenotype of elastin-producing cells. An area of elastin research that has attracted much interest over the past 3-5 years is the investigation of connective tissue diseases in skin. Just as the skin has been used successfully to characterize diseases involving collagen, new and interesting findings have identified genetic as well as environmentally- induced skin diseases associated with elastin. It is felt that scheduling sessions on elastin diseases early in the week will help focus the meeting and should assist subsequent speakers as well as conference attendees in viewing the fundamental biology of the elastin molecule in the context of the disease state. The proposed meeting will bring together basic scientists from a variety of disciplines. Overall, the conference intends to enhance our understanding of the nature of elastin and its role in biology and pathobiology, to critically review current directions of research, and to stimulate new avenues of exploration regarding this important connective tissue protein. Attendees of the previous meetings enthusiastically agree that the Gordon Conference provides a most important format for communication among investigators in this field.

这项建议寻求支持第五届两年一度的戈登 弹性蛋白研究会议。 会议将提供一个 交流新信息的重要形式， 弹性蛋白结构新概念的发展 及其前体，其作为生物弹性体的作用， 的弹性蛋白基因和控制其表达在 分子、细胞和组织水平，弹性蛋白相关 大分子，弹性蛋白降解的酶机制 和弹性蛋白分解酶的生理抑制剂。 最 重要的是，1987年会议的形式已经安排好， 强调与弹性蛋白紊乱有关的疾病 内容或结构。 肺部疾病将是一个主要的焦点， 第二次会议专门讨论纤维化和间质性疾病， 肺动脉高压的治疗 在一次会议上， 血管学科与专业知识的生长因子和 炎症细胞的产物，因为这些分子可能发挥作用， 在调节产生弹性蛋白的表型中的重要作用 细胞 弹性蛋白研究领域吸引了很多 在过去的3-5年里， 皮肤组织疾病 就像皮肤已经成功使用 表征疾病涉及胶原蛋白，新的和有趣的 研究结果已经确定了遗传和环境- 诱发与弹性蛋白有关的皮肤病。 有人认为 在本周早些时候安排弹性蛋白疾病的会议将有所帮助 会议的重点，并应协助随后发言，以及 会议与会者在查看基础生物学的 弹性蛋白分子在疾病状态的背景下。 拟议的会议将汇集来自不同国家的基础科学家 各种学科。 总的来说，会议旨在加强 我们对弹性蛋白的性质及其在生物学中的作用的理解 和病理生物学，批判性地审查当前的方向， 研究，并鼓励探索新的途径， 这种重要的结缔组织蛋白。 的与会者 前几次会议一致认为，戈登 会议为交流提供了最重要的形式 在这个领域的研究者中。