1987 GORDON RESEARCH CONFERENCE ON ELASTIN

这项提议寻求对第五届戈登半年期的支持 弹性蛋白研究会议。这次会议将提供一个 交流新信息的重要格式 关于弹性蛋白结构的新概念的发展 以及它的前体，它作为生物弹性体的作用，分析 弹性蛋白基因及其表达的调控 分子、细胞和组织水平，弹性蛋白相关 弹力蛋白降解的大分子、酶机制 和弹性分解酶的生理抑制剂。多数 重要的是，1987年会议的安排已经安排好。 强调与弹性蛋白紊乱相关的疾病 内容或结构。肺部疾病将是一个主要的焦点。 专门讨论纤维化和间质性疾病的会议和第二次会议 关于肺动脉高压的会议。在一个专门的会议上 对血管学科具有生长因子和 炎性细胞产物，因为这些分子可能在 在调节弹性蛋白产生表型中的重要作用 细胞。弹性蛋白研究的一个领域吸引了很多人 过去3-5年的兴趣是对连接词的研究 皮肤中的组织疾病。就像皮肤已经被成功地使用一样 描述涉及胶原蛋白的疾病，新的和有趣的 研究结果确认了遗传和环境因素-- 与弹性蛋白相关的诱发皮肤病。人们感觉到 在本周初安排有关弹性蛋白疾病的会议将有所帮助 将会议重点放在会议上，并应协助后续发言者以及 参加会议的人观看了生物的基本生物学 弹性蛋白分子在疾病状态的背景下。 拟议中的会议将汇集来自世界各地的基础科学家 各式各样的学科。总体而言，会议打算加强 我们对弹性蛋白的性质及其在生物学中的作用的理解 和病理生物学，以批判性地审查当前的方向 研究，并鼓励探索新的途径 这种重要的结缔组织蛋白。参会嘉宾 之前的会议都热情地同意戈登 会议提供了最重要的交流形式 在这一领域的调查人员中。

This proposal seeks support for the fifth bi-annual Gordon Research Conference on Elastin. The conference will provide an important format for the exchange of new information and the development of new concepts concerning the structure of elastin and its precursor, its role as a biological elastomer, the analysis of the elastin gene and the control of its expression at the molecular, cell and tissue levels, elastin-associated macromolecules, enzymatic mechanisms of degradation of elastin and physiological inhibitors of elastolytic enzymes. Most importantly, the format for the 1987 meeting has been arranged to emphasize disease associated with perturbations in elastin content or structure. Lung disease will be a major focus with one session devoted to fibrotic and interstitial diseases and a second session dealing with pulmonary hypertension. in a session devoted to vascular disciplines with expertise on growth factors and inflammatory cell products since these molecules may play an important role in modulating the phenotype of elastin-producing cells. An area of elastin research that has attracted much interest over the past 3-5 years is the investigation of connective tissue diseases in skin. Just as the skin has been used successfully to characterize diseases involving collagen, new and interesting findings have identified genetic as well as environmentally- induced skin diseases associated with elastin. It is felt that scheduling sessions on elastin diseases early in the week will help focus the meeting and should assist subsequent speakers as well as conference attendees in viewing the fundamental biology of the elastin molecule in the context of the disease state. The proposed meeting will bring together basic scientists from a variety of disciplines. Overall, the conference intends to enhance our understanding of the nature of elastin and its role in biology and pathobiology, to critically review current directions of research, and to stimulate new avenues of exploration regarding this important connective tissue protein. Attendees of the previous meetings enthusiastically agree that the Gordon Conference provides a most important format for communication among investigators in this field.