REVERSE CHOLESTEROL TRANSPORT

几组人类患者的风险增加， 动脉粥样硬化显示序列中一致的异常 胆固醇的逆向转运（“reverse cholesterol transport”） 胆固醇从外周细胞转移到肝脏。 的目的 这些试点研究是为了确定狒狒，一个模型， 对于人类大血管疾病，在血浆中具有胆固醇 转运途径与在人类中发现的相似;以及 无论是遗传因素还是环境因素， 动脉粥样硬化和胆固醇转运的发病率 在狒狒身上也有类似的效果。 胆固醇逆向转运速率及其组分 步骤（胆固醇转运到血浆中;胆固醇 血浆中卵磷脂：胆固醇酯化作用 酰基转移酶;胆固醇酯转移）将被测量 在狒狒血浆中。 最初的研究将是反应率， 正常动物空腹血浆。 后续测量 将存在于具有家族遗传的动物的血浆中， 高或低LDL/HDL比率或HDL和LDL水平 血浆减少。 餐后脂血症，刺激 胆固醇逆向转运在正常血脂的人，将是 检查其对胆固醇逆向转运的影响， 正常和异常脂蛋白血症的脂蛋白组成 狒狒 所获得的数据将表明 产生和分布胆固醇酯的机制 人类血浆在狒狒体内繁殖。 如果这样的 相似性是由这些试点实验，它将使 可能的调查是否胆固醇沉积 大血管的异常与 在相同动物的血浆中的胆固醇代谢。

Several groups of human patients at increased risk of atherosclerosis show consistent abnormalities in the sequence of reactions ("reverse cholesterol transport") which carries cholesterol from peripheral cells to the liver. The purpose of these pilot studies is to determine whether the baboon, a model for human macrovascular disease, has in plasma a cholesterol transport pathway similar to that identified in humans; and whether genetic or environmental factors which modify the incidence of atherosclerosis and cholesterol transport in humans, have similar effects in the baboon. The rate of reverse cholesterol transport and its component steps (cholesterol transport into plasma; cholesterol esterification in plasma by lecithin: cholesterol acyltransferase; cholesteryl ester transfer) will be measured in baboon plasma. Initial studies will be of reaction rates in the fasting plasma of normal animals. Subsequent measurements will be in the plasma of abimals with familial inheritance of high or low LDL/HDL ratios or with both HDL and LDL levels decreased in plasma. Postprandial lipemia, which stimulates reverse cholesterol transport in normolipemic humans, will be examined for its effect on reverse cholesterol transport and lipoprotein composition in normal and dyslipoproteinemic baboons. The data obtained will indicate the extent to which the mechanisms which generate and distribute cholesteryl esters in human plasma are reproduced in the baboon. If such a similarity is shown by these pilot experiments, it will make possible an investigation of whether cholesterol deposition in the large vessels is directly related to abnormalities of cholesterol metabolism in the plasma of the same animals.