PREVALENCE OF G-6-PD DEFICIENCY IN GLAUCOMA PATIENTS

青光眼患者 G-6-PD 缺乏症的患病率

• 批准号: 3426383
• 负责人: DAVID A LEE
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-07-01 至 1988-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3426383
• 关键词: African American; disease /disorder proneness /risk; eye disorder diagnosis; glaucoma; glycogen storage disease type I; human subject; intraocular aqueous flow; male; mass screening

One theory of the biochemical etiology of primary open angle glaucoma (POAG) is that oxidative damage to the tissues of the aqueous outflow system causes a reduction in facility of outflow. In a preliminary study, we have found glucose-6-phosphate dehydrogenase (G-6-PD) deficiency in 7 of 30 black male POAG patients (23%), twice the rate we would expect in the black male population. One hundred eighty (180) black male patients with POAG (cases) and 180 black male patients from other clinics (controls) will be screened for G-6-PD deficiency to determine whether this enzyme deficiency is more common in POAG patients.

原发性开角青光眼的生化病因的一种理论 （POAG）是对水流组织的氧化损害 系统导致流出设施的减少。 在一项初步研究中 我们发现在7的7中发现葡萄糖-6-磷酸脱氢酶（G-6-PD）缺乏症 30名黑人男性POAG患者（23％），我们期望的率是 黑人男性人口。 一百八十（180）个黑人男性POAG（病例）和180例 将筛选来自其他诊所的黑人男性患者（对照） G-6-PD缺乏以确定这种酶缺乏是否更多 在POAG患者中常见。

项目成果

Collagen-shield delivery of gentamicin and vancomycin.

庆大霉素和万古霉素的胶原盾递送。

• DOI: 10.1001/archopht.1988.01060140767052
• 发表时间: 1988
• 期刊: Archives of ophthalmology (Chicago, Ill. : 1960)
• 作者: Phinney,RB;Schwartz,SD;Lee,DA;Mondino,BJ
• 通讯作者: Mondino,BJ