1986 GORDON RESEARCH CONFERENCE--ENZYMES & COENZYMES

要求支持戈登酶研究会议， 辅酶和代谢途径，将在金博尔联盟举行 学院，梅里登，新罕布什尔州从1986年6月29日至7月4日。 这 会议的目的是通过促进自由， 和非正式的信息交流， 化学和生物学之间的界面。 本次会议的基本主题包括详细研究 酶促反应和参与这些反应的辅因子，以及如何 这些酶的活性和整个代谢途径受到控制。 今年的会议将特别强调 定点突变用于酶机制的研究。 包括 将分析氨基酸替换的后果， 预测改性蛋白质的性质，并评估其 结构变化对理解酶起源的意义 催化作用 将在涉及以下问题的谈判之间保持平衡： 介绍详细的实验结果与那些处理 开发新技术。 在所有情况下，预定的发言者都是 根据他们在研究和演示方面的卓越表现而选择 重大的新进展。 参加这次会议的 重组DNA技术、X射线晶体学、物理学 有机化学、生物有机化学和酶机制应 带来新的令人兴奋的合作。

Support is requested for the Gordon Research Conference on Enzymes, Coenzymes and Metabolic Pathways which will be held at Kimball Union Academy, Meriden, New Hampshire from June 29 through July 4, 1986. This conference is intended to extend the frontiers of science by fostering free and informal exchange of information among scientists who function at the interface between chemistry and biology. The underlying themes of this conference involve detailed studies of enzymatic reactions and the cofactors involved in these reactions and how the activity of these enzymes and whole metabolic pathways are controlled. This year the conference will have a special emphasis on applications of site-directed mutagenesis for the study of enzyme mechanisms. Included will be analysis of the consequences of amino acid replacements in order to predict the properties of the modified proteins and to evaluate the implications of structural changes for understanding the origins of enzyme catalysis. A balance will be maintained between talks concerned with presentation of detailed experimental results with those dealing with the development of new techniques. In all cases, scheduled speakers have been selected on the basis of their excellence in research and the presentation of significant new advances. The participation in this conference of experts in recombinant DNA techniques, x-ray crystallography, physical organic chemistry, bio-organic chemistry and enzyme mechanisms should result in new and exciting collaborations.