1986 GORDON RESEARCH CONFERENCE--ENZYMES & COENZYMES

请求支持戈登酵素研究会议， 辅酶和新陈代谢途径将在金博尔联盟举行 学院，1986年6月29日至7月4日，新罕布夏州梅里登。这 会议的目的是通过促进自由，扩展科学的前沿 以及科学家之间的非正式信息交流 化学和生物学之间的接口。 这次会议的基本主题涉及对 酶反应及参与这些反应的辅因子及其作用方式 这些酶的活性和整个代谢途径是受控制的。 今年的会议将特别强调应用 用于酶机制研究的定点突变。包括在内 将分析氨基酸替代的后果，以便 对修饰蛋白的性质进行预测并对其进行评价 结构变化对理解酶起源的意义 催化作用。将在涉及以下问题的谈判之间保持平衡 详细的实验结果介绍与那些处理 新技术的发展。在所有情况下，预定的演讲者都是 根据他们在研究和演讲方面的卓越表现入选 重大的新进展。参加这次会议的情况 重组DNA技术、X射线结晶学、物理学方面的专家 有机化学、生物有机化学和酶机理应 带来新的、令人兴奋的合作。

Support is requested for the Gordon Research Conference on Enzymes, Coenzymes and Metabolic Pathways which will be held at Kimball Union Academy, Meriden, New Hampshire from June 29 through July 4, 1986. This conference is intended to extend the frontiers of science by fostering free and informal exchange of information among scientists who function at the interface between chemistry and biology. The underlying themes of this conference involve detailed studies of enzymatic reactions and the cofactors involved in these reactions and how the activity of these enzymes and whole metabolic pathways are controlled. This year the conference will have a special emphasis on applications of site-directed mutagenesis for the study of enzyme mechanisms. Included will be analysis of the consequences of amino acid replacements in order to predict the properties of the modified proteins and to evaluate the implications of structural changes for understanding the origins of enzyme catalysis. A balance will be maintained between talks concerned with presentation of detailed experimental results with those dealing with the development of new techniques. In all cases, scheduled speakers have been selected on the basis of their excellence in research and the presentation of significant new advances. The participation in this conference of experts in recombinant DNA techniques, x-ray crystallography, physical organic chemistry, bio-organic chemistry and enzyme mechanisms should result in new and exciting collaborations.