CELLULAR AND MOLECULAR BIOLOGY OF THE VACUOLAR SYSTEM

此申请是为第十二届戈登会议上的溶酶体， 1986年6月23日至29日。 这将是一次跨学科的会议， 演讲者和与会者来自细胞生物学领域， 生物化学、遗传学、微生物学、生理学和病理学。 其重点 将是关于溶酶体和相关细胞器的分子方法。 "溶酶体"的领域现在被广泛地认为不仅包括溶酶体， 经典的降解体，但也内吞作用的细胞器 （被膜小凹和内体），胞吐作用（高尔基体和分泌囊泡）， 以及溶酶体及其内容物（内质网）的生物发生 Golgi）。 本领域的现有技术包括识别 负责内吞作用、酸化、运输的特定分子 细胞器和降解功能之间的联系。 结构研究，如 准确的，因为目前的知识允许，将提出有关 蛋白质（例如，酶和受体），并尽可能地， 它们被编码的核酸。 遗传学研究渗透到 几乎每一次会议都包括关于使用突变体和/或 重组DNA技术。 39名受邀科学家，包括演讲者和主席， 列在拟议的计划;他们已被选定的基础上， 最近对该领域的重大研究贡献。 新增10名发言人 将被选为重要的发展发生。 我们已经尽力了， 有可能邀请年轻的研究人员与新的结果。 其他 参加者可透过海报展示他们的作品。 会议 旨在促进科学家之间的交流和讨论 在一个快速发展的领域，跨越既定的学科， 生物医学研究

This application is for the twelth Gordon Conference on Lysosomes, to be held June 23-29, 1986. It will be an interdisciplinary meeting, with speakers and participants drawn from the fields of cell biology, biochemistry, genetics, microbiology, physiology and pathology. Its focus will be on molecular approaches to lysosomes and related organelles. The field of "lysosomes" is now broadly perceived to include not only the classical degradative bodies, but also the organelles of endocytosis (coated pits and endosomes), of exocytosis (Golgi and secretory vesicles), and of biogenesis of lysosomes and their contents (endoplasmic reticulum and Golgi). The state of the art in the field includes the identification of specific molecules responsible for endocytosis, acidification, transport between organelles and degradative functions. Structural studies, as precise as current knowledge permits, will be presented for relevant proteins (e.g., enzymes and receptors) and whenever possible, for the nucleic acids in which they are encoded. Genetic studies permeate the program; nearly every session includes talks on the use of mutants and/or recombinant DNA technology. Thirty nine invited scientists, including speakers and chairpersons, are listed on the proposed program; they have been selected on the basis of major recent research contributions to the field. Ten additional speakers will be selected as important developments occur. We have tried as far as possible to invite younger investigators with new results. Other participants will be able to present their work in posters. The Conference is designed to facilitate communication and discussion between scientists in a fast-moving field that cuts across established disciplines of biomedical research.