CELLULAR AND MOLECULAR BIOLOGY OF THE VACUOLAR SYSTEM

液泡系统的细胞和分子生物学

• 批准号: 3434948
• 负责人: ARI H HELENIUS
• 金额: $ 0.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-06-09 至 1987-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434948
• 关键词: Golgi apparatus; X ray crystallography; endoplasmic reticulum; genetic manipulation; genetic recombination; inborn lysosomal enzyme disorder; lysosomes; mutant; organelles; pinocytosis; proteolysis; travel; vesicle /vacuole

This application is for the twelth Gordon Conference on Lysosomes, to be held June 23-29, 1986. It will be an interdisciplinary meeting, with speakers and participants drawn from the fields of cell biology, biochemistry, genetics, microbiology, physiology and pathology. Its focus will be on molecular approaches to lysosomes and related organelles. The field of "lysosomes" is now broadly perceived to include not only the classical degradative bodies, but also the organelles of endocytosis (coated pits and endosomes), of exocytosis (Golgi and secretory vesicles), and of biogenesis of lysosomes and their contents (endoplasmic reticulum and Golgi). The state of the art in the field includes the identification of specific molecules responsible for endocytosis, acidification, transport between organelles and degradative functions. Structural studies, as precise as current knowledge permits, will be presented for relevant proteins (e.g., enzymes and receptors) and whenever possible, for the nucleic acids in which they are encoded. Genetic studies permeate the program; nearly every session includes talks on the use of mutants and/or recombinant DNA technology. Thirty nine invited scientists, including speakers and chairpersons, are listed on the proposed program; they have been selected on the basis of major recent research contributions to the field. Ten additional speakers will be selected as important developments occur. We have tried as far as possible to invite younger investigators with new results. Other participants will be able to present their work in posters. The Conference is designed to facilitate communication and discussion between scientists in a fast-moving field that cuts across established disciplines of biomedical research.

此申请是针对第十二戈登溶酶体会议 1986年6月23日至29日举行。这将是一次跨学科会议，与 来自细胞生物学领域的演讲者和参与者， 生物化学，遗传学，微生物学，生理和病理学。 它的重点 将采用溶酶体和相关细胞器的分子方法。 现在，“溶酶体”的领域现在被广泛认为包括 经典降解物体，也是内吞作用的细胞器 （涂层坑和内体），胞吐作用（高尔基和分泌囊泡）， 以及溶酶体及其含量的生物发生（内质网 和高尔基）。 该领域的艺术状况包括身份证明 负责内吞作用，酸化，转运的特定分子的 在细胞器和降解功能之间。 结构研究，AS 精确作为当前知识允许的相关性 蛋白质（例如酶和受体），并在可能的情况下 它们编码的核酸。 遗传研究渗透 程序;几乎每个会议都包括有关使用突变体和/或 重组DNA技术。 39位受邀科学家，包括演讲者和主席，是 在拟议的计划中列出；他们是根据 最近对该领域的主要研究贡献。 另外十名演讲者 将被选为重要的发展。 我们已经尝试了 可能邀请年轻的调查员取得新的结果。 其他 参与者将能够在海报中介绍他们的作品。 会议 旨在促进科学家之间的沟通和讨论 在一个快速移动的领域中，跨越了跨越的学科 生物医学研究。