CELLULAR AND MOLECULAR BIOLOGY OF THE VACUOLAR SYSTEM

本申请是关于溶酶体的第十二届戈登会议， 于1986年6月23日至29日举行。这将是一次跨学科的会议， 来自细胞生物学领域的演讲者和参与者， 生物化学、遗传学、微生物学、生理学和病理学。它的焦点 将介绍溶酶体和相关细胞器的分子方法。 “溶酶体”这一领域现在被广泛认为不仅包括 经典的降解体，也是内吞作用的细胞器 胞吐作用(高尔基体和分泌囊)， 和溶酶体的生物发生及其内容物(内质网 和高尔基)。该领域的最新技术包括身份识别 负责内吞、酸化、运输的特定分子 细胞器和退化功能之间的关系。结构研究，如 在现有知识允许的情况下，将为相关人员提供 蛋白质(例如，酶和受体)，并尽可能地为 编码它们的核酸。基因研究渗透到 计划；几乎每一次会议都包括关于使用突变体和/或 重组DNA技术。 包括演讲者和主席在内的39名受邀科学家是 在拟议方案中列出；它们是在以下基础上选择的 最近对该领域的主要研究贡献。另外十个扬声器 将随着重要事态的发展而被选中。到目前为止，我们已经尝试了 有可能邀请更年轻的调查人员带来新的结果。其他 参与者将能够在海报中展示他们的作品。《大会》 旨在促进科学家之间的交流和讨论 在一个快速发展的领域，它跨越了 生物医学研究。

This application is for the twelth Gordon Conference on Lysosomes, to be held June 23-29, 1986. It will be an interdisciplinary meeting, with speakers and participants drawn from the fields of cell biology, biochemistry, genetics, microbiology, physiology and pathology. Its focus will be on molecular approaches to lysosomes and related organelles. The field of "lysosomes" is now broadly perceived to include not only the classical degradative bodies, but also the organelles of endocytosis (coated pits and endosomes), of exocytosis (Golgi and secretory vesicles), and of biogenesis of lysosomes and their contents (endoplasmic reticulum and Golgi). The state of the art in the field includes the identification of specific molecules responsible for endocytosis, acidification, transport between organelles and degradative functions. Structural studies, as precise as current knowledge permits, will be presented for relevant proteins (e.g., enzymes and receptors) and whenever possible, for the nucleic acids in which they are encoded. Genetic studies permeate the program; nearly every session includes talks on the use of mutants and/or recombinant DNA technology. Thirty nine invited scientists, including speakers and chairpersons, are listed on the proposed program; they have been selected on the basis of major recent research contributions to the field. Ten additional speakers will be selected as important developments occur. We have tried as far as possible to invite younger investigators with new results. Other participants will be able to present their work in posters. The Conference is designed to facilitate communication and discussion between scientists in a fast-moving field that cuts across established disciplines of biomedical research.