PROTEIN FOLDING AND ASSEMBLY IN THE CELL

细胞内的蛋白质折叠和组装

• 批准号: 3435079
• 负责人: MARY-JANE GETHING
• 金额: $ 0.3万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-06-01 至 1991-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435079
• 关键词: meeting /conference /symposium; nuclear magnetic resonance spectroscopy; protein biosynthesis; protein engineering; protein structure; transport proteins; transposon /insertion element

This is an application for partial funding of a conference on "Protein Folding and Assembly in the Cell" to be held under the auspices of the Federation of American Societies for Experimental Biology (FASEB), from June 24 to 29, 1990 in Copper Mountain, Colorado. The conference is intended to bring together for the first time groups of academic scientists and biotechnologists who have been working in very diverse areas but have now have a rapidly converging interest in protein folding. Speakers and participants at the conference will include researchers involved in a variety of studies on protein folding, protein transport, protein degradation and the stress protein family. Among these researchers will be those working on theoretical aspects and in vitro systems, as well as those working in vivo on systems as diverse as prokaryotes, yeasts, plants and mammalian cells. The central theme will be how protein folding is achieved and regulated within the cell. The conference will consist of nine scientific sessions, each with four to six speakers and a discussion leader. Topics to be covered are: "Structural Determinants of Protein Folding - Theoretical and In Vitro Studies", "Genetic Studies of Protein Folding", "Cellular Proteins Involved in Protein Folding (I and II)", "Role of Folding in Protein Translocation Across Membranes", "Protein Folding and Intracellular Transport", "Folding and Assembly of Heteromeric Multisubunit Proteins", "Properties of Hybrid Proteins" and "Protein Misfolding, Aggregation and Intracellular Degradation". In addition a poster session will be held daily to allow more junior participants to present their work. Participation will be limited to 150 scientists (including the speakers and discussion leaders), who will be selected on the basis of their expertise and interests as most likely to contribute to a stimulating and productive environment.

这是一份关于“蛋白质”会议部分资金的申请 在牢房中折叠和组装”的会议， 美国实验生物学学会联合会（FASEB） 1990年6月24日至29日在科罗拉多的铜山。裁谈会 旨在第一次将学术界的科学家聚集在一起， 和生物技术专家，他们一直在非常不同的领域工作， 现在对蛋白质折叠的兴趣迅速聚集。扬声器和 与会者将包括参与一项 对蛋白质折叠、蛋白质转运、蛋白质 降解和应激蛋白家族。在这些研究人员中， 那些从事理论方面和体外系统工作的人，以及那些 在原核生物、酵母菌、植物等多种系统中进行体内研究， 哺乳动物细胞中心主题将是蛋白质折叠是如何实现的 并在细胞内调节。 会议将包括九个科学会议，每个会议有四个， 六位发言人和一位讨论负责人。将涵盖的主题是：“结构 蛋白质折叠的决定因素-理论和体外研究”， “蛋白质折叠的遗传学研究”，“参与蛋白质折叠的细胞蛋白质”， 蛋白质折叠（I和II）"，“折叠在蛋白质易位中的作用 蛋白质折叠与细胞内转运 异聚体多亚基蛋白质的组装”，“杂合物的性质 蛋白质”和“蛋白质错误折叠，聚集和细胞内 退化”。此外，每天还将举行海报会议， 年轻的参与者介绍他们的工作。参与将限于 150名科学家（包括演讲者和讨论负责人），他们将 根据他们的专业知识和兴趣选择， 有助于创造一个激励和富有成效的环境。