LASER-INDUCED NOVEL POTENTIAL ANTICANCER INDOLES

脱氧核糖核酸（DNA）被认为是一种 许多临床上有用的抗肿瘤剂。 建议的目标 研究是开发新的和更有效的DNA反应药物 用于人类癌症的光动力激光诱导化疗，或 灭活病毒病原体或两者。 此外，该研究还描述了 这一建议将有助于现有的知识的影响， 激光-物质相互作用的机制，因为激光诱导的损伤 特别是在细胞和亚细胞水平的物质是知之甚少 目前，这是许多研究小组深入研究的课题。 本研究的目的是获取和分析 吸收光谱、荧光光谱和电泳图谱 DNA和/或一些新的介离子吲哚衍生物的密度痕量 在纳秒Nd：YAG激光照射之前和之后。 吸收 并使用Scatchard方程分析荧光数据。 将通过HPLC分析光产物，并通过CHN元素分析表征 通过IR、UV、1HNMR、13 C NMR和MS分析和光谱。

Deoxyribonucleic acid (DNA) is believed to be the molecular target of a number of clinically useful antitumor agents. The goal of the proposed research is the development of new and more effective DNA reactive drugs for the photodynamic laser-light induced chemotherapy of human cancers or inactivation of viral pathogens or both. Additionally, the study described in this proposal will contribute to existing knowledge of the effects and mechanisms of laser-matter interaction because laser-induced damage to matter especially at cellular and sub-cellular level is poorly understood at this time and is the subject of intense study of many research groups. The aim of the present study is the acquisition and analysis of the absorption spectra, fluorescence spectra and the electrophoretic densitometric traces of DNA and/or some novel mesoionic indole derivatives prior to and subsequent to nanosecond Nd:YAG laser irradiation. Absorption and fluorescence data will be analyzed using Scatchard equation. Photoproducts will be analyzed by HPLC and characterized by CHN elemental analysis and spectroscopically by IR, UV, 'HNMR, 13C NMR and MS.