NEW THERAPEUTIC INITIATIVES IN METHADONE MAINTENANCE

美沙酮维持治疗的新治疗举措

• 批准号: 3441665
• 负责人: LAWRENCE S BROWN
• 金额: $ 206.51万
• 依托单位: START TREATMENT AND RECOVERY CENTERS INC
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-30 至 1994-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3441665
• 关键词: AIDS; HIV infections; acupuncture /acupressure; communicable disease transmission; disease /disorder proneness /risk; drug abuse chemotherapy; drug addiction; drug administration routes; ethnic group; health surveys; human subject; intravenous drug abuse; methadone; self help organization; sex behavior

AIDs continues to represent a critical issue for society. Despite significant developments on many fronts, the somber morbidity and mortality statistics remain. Intravenous drug abusers (IVDAs) comprise the second largest risk group and play a significant role in the prevalence of AIDS among adult females, heterosexuals, the pediatric age group, ethnic/racial minorities and New Yorkers. While drug abuse treatment has been advance as an HIV prevention strategy, many areas of difficulty exists in the delivery of drug treatment today. Concerned about the implications this holds for the nearly 2,100 patients under its care, the Addiction Research and Treatment Corporation (ARTC) proposes to establish a Treatment Research Unit (TRU) with a five year plan: 1. To increase enrollment in drug treatment of 300 persons dependent upon psychoactive substances that are associated with parenteral routes of administration or that are associated with disinhibiting behaviors that place these persons at risk of HIV infection; 2. To evaluate the efficacy of various pharmacologic and non- pharmacologic interventions that will reduce drug/sex behaviors associated with HIV transmission of HIV disease progression among persons enrolled in drug treatment; and 3. To identify factors (demographic, behavioral, and biomedical) associated with the success of various interventions to reduce HIV-associated transmission behaviors. Both survey/epidemiologic and ethnographic methods will be utilized to evaluate pharmacologic protocols, acupuncture, clinically guided self help and primary medical care study designs. The major theme of this Treatment Research Center (TRU) is the investigation of methods to improve methadone maintenance treatment. During the life of this TRU, flexibility will allow the examination of not only what interventions work and do not work, but also help explain why some approaches work in some circumstances and not in others.

艾滋病仍然是社会的一个关键问题。尽管 许多方面的重大事态发展，阴郁的发病率和 死亡统计数字仍然存在。静脉注射吸毒者包括 是第二大风险群体，并在 艾滋病在成年女性、异性恋者、儿童年龄中的流行率 群体、少数族裔和纽约人。在吸毒的同时 治疗已被推进为艾滋病毒预防战略，许多领域 今天，在提供药物治疗方面存在困难。 担心这对近2100名患者的影响 在它的照顾下，成瘾研究和治疗公司(ARTC) 建议成立一个治疗研究单位(TRU)，为期五年 计划：1.增加戒毒治疗招生300人 依赖于与以下物质相关的精神活性物质 肠外给药途径或与 解除将这些人置于艾滋病毒风险中的行为 2.评价各种药理与非药物治疗的疗效。 将减少药物/性行为的药物干预 与艾滋病毒传播有关的艾滋病毒疾病在人群中的进展 参加戒毒治疗；以及3.确定因素(人口统计， 行为学和生物医学)与各种 减少艾滋病毒相关传播行为的干预措施。两者都有 将利用调查/流行病学和人种学方法 评估药物方案、针灸、临床自我指导 帮助和初级医疗保健研究设计。这次会议的主要主题是 治疗研究中心(TRU)是对治疗方法的研究 改进美沙酮维持治疗。在这个TRU的生命中， 灵活性将不仅允许审查哪些干预措施 工作和不工作，但也有助于解释为什么一些方法在 在某些情况下，而在其他情况下则不是。