KETOGENIC DIET IN CHILDREN WITH MEDICALLY REFRACTORY SEIZURE

难治性癫痫儿童的生酮饮食

• 批准号: 6278074
• 负责人: LAWRENCE S BROWN
• 金额: $ 2.4万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278074
• 关键词: bioenergetics; body composition; bone density; child (0-11); clinical research; diet therapy; epilepsy; human subject; human therapy evaluation; ketone body; nutrition related tag

The Ketogenic Diet was first described as a non-pharmacologic therapy for epileptic seizures in 1921. This therapy has undergone periods of popularity and disfavor, the latter related primarily to the rigors of the diet. However, in recent years the Ketogenic Diet has regained popularity as therapy for a select group of children whose seizures have not responded to medications or in whom side effects of the medications have become unacceptable. As part of a current comprehensive study of the Ketogenic Diet which will address questions about methods of diet initiation, and measurement of regional brain pH, we plan to evaluate the effects of the Ketogenic Diet on growth, body composition, resting energy expenditure, substrate utilization and bone density. To date, 25 patients have been enrolled (12 girls and 13 boys). The age ranged from 10 months to 17 years, with an average of 8 years. Preliminary analysis of our data shows: 1) The Ketogenic Diet produces an overall decrease in resting energy expenditure (REE) with the largest decline between the baseline and 1-month follow-up. 2) The Ketogenic Diet produces a loss of BMD despite supplementation. 3) The Ketogenic Diet produces an initial weight loss followed by weight stabilization.

生酮饮食最初被描述为一种非药物治疗， 1921年癫痫发作这种疗法经历了几个时期， 他的话，让文龙的身子猛然一僵，随即便软倒在地。 饮食.然而，近年来生酮饮食又重新流行起来， 作为一种治疗选择组的儿童， 对药物有反应或药物的副作用 变得不可接受。作为目前全面研究 生酮饮食，将解决有关饮食方法的问题 启动，并测量局部脑pH值，我们计划评估 生酮饮食对生长、身体组成、静息能量的影响 消耗、基质利用和骨密度。 迄今为止，已招募了25名患者（12名女孩和13名男孩）。岁 年龄10个月~ 17岁，平均8岁。初步 我们的数据分析显示：1）生酮饮食产生总体 静息能量消耗（REE）下降幅度最大 在基线和1个月随访之间。2)生酮饮食产生 尽管有补充，但骨密度仍有损失。3)生酮饮食会产生 最初的体重减轻，然后体重稳定。